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Viral and Host Strategies for Regulation of Latency and Reactivation in Equid Herpesviruses

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Title Viral and Host Strategies for Regulation of Latency and Reactivation in Equid Herpesviruses
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Creator Baldev R. Gulati, Himanshu Sharma, T. Riyesh, Sandip K. Khurana , Sanjay Kapoor
 
Subject Equid herpesvirus, EHV1, EHV4, latency, reactivation, pathogenesis
 
Description Not Available
Nine members of the family Herpesviridae infect equines and two of them (EHV1 and EHV4)
are the globally significant pathogens causing respiratory disease, abortion and more rarely
paralysis. The ability of equid herpesviruses to establish life-long latent infection in lymphoid and
neural tissues with periodic reactivation and shedding is central to the maintenance of these
viruses in horse populations. Over 50% of horses become latently infected after infection with EHV1
and EHV4. During latency, expression of viral genes is highly restricted with expression of few or
no viral proteins. The recent scientific advances have provided insight into the mechanism of
equine herpesvirus pathogenesis, including latency. The establishment of latent infection is highly
coordinated process regulated by inter-play of viral, host and environmental factors. In this article,
we review how molecular, cellular and viral regulatory mechanisms influence the switch between
latent and lytic infections.
Not Available
 
Date 2018-11-29T10:28:58Z
2018-11-29T10:28:58Z
2015-10-01
 
Type Journal
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/14175
 
Language English
 
Relation Not Available;
 
Publisher Not Available