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Polymorphisms in pattern recognition receptor genes of indigenous and White Leghorn breeds of chicken

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Title Polymorphisms in pattern recognition receptor genes of indigenous and White Leghorn breeds of chicken
Not Available
 
Creator Santosh Haunshi, Arun Kumar Burramsetty, Kannaki Ramasamy, and Rudra Nath Chatterjee
 
Subject PRR, Polymorphism, Chicken, Indigenous
 
Description Not Available
Functional polymorphisms in pattern recognition receptors (PRRs) modulate innate immunity and
play a crucial role in resistance or susceptibility to diseases. The present study was carried out to explore polymorphic patterns in the coding sequences of PRR genes TLR3, TLR1LA (TLRs), MDA5, LGP2 (RLRs) and
NOD1 (NLR) in chicken breeds of India, namely Ghagus (GH), Nicobari (NB) and the exotic White Leghorn
(WLH) breed. Out of 209 SNPs observed in five genes among three breeds, 117 were synonymous (Syn) and
92 were non-synonymous (NS) SNPs. In TLR genes the highest polymorphism was observed in NB (16, 28)
compared to GH (14, 16) and WLH (13, 19) breeds. In the MDA5 gene the highest polymorphism was observed in GH (12) compared to NB (eight) and WLH (four) breeds. However, an almost similar level of polymorphism was observed in the LGP2 gene among the three breeds. In the NOD1 gene, the highest polymorphism was observed in NB (27), followed by WLH (11) and GH (10) breeds. The overall highest number of SNPs was observed in NB (90), followed by GH (62) and the WLH (57) breed. With regard to variation in polymorphism among different classes of PRRs, the study revealed the highest polymorphism in TLRs compared to NOD1 and the RLR class of PRRs. Further, the domain locations of various Syn and NS SNPs in each PRR among the three breeds were identified. In silico analysis of NS SNPs revealed that most of them had a neutral effect on protein function. However, two each in TLR1LA and LGP2 and one in the MDA5 gene were predicted to be deleterious to protein function. The present study unravelled extensive polymorphism in the coding sequences of the TLR and NLR class of PRR genes, and the polymorphism was higher in indigenous chicken breeds.
Science and Engineering Research Board
 
Date 2019-05-06T09:24:52Z
2019-05-06T09:24:52Z
2018-11-12
 
Type Research Paper
 
Identifier Haunshi, S., Arun Kumar B., Kannaki T. R and Chatterjee, R. N. 2018. Polymorphisms in pattern recognition receptor genes of indigenous and White Leghorn breeds of chicken. Archives Animal Breeding, 61: 441–449.
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http://krishi.icar.gov.in/jspui/handle/123456789/19217
 
Language English
 
Relation Not Available;
 
Publisher Copernicus Publications on behalf of the Leibniz Institute for Farm Animal Biology