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Molecular epidemiology of rabies virus circulating in domestic animals in India

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Title Molecular epidemiology of rabies virus circulating in domestic animals in India
Not Available
 
Creator Manjunatha Reddy GB
Krishnappa S
Vinayagamurthy B
Singh R
Singh KP
Saminathan M
Sajjanar B
Rahman H
 
Subject Animals
Epidemiology
India
N-gene
Phylogenetic analysis
Rabies
 
Description Not Available
Rabies is a neglected viral zoonotic disease affecting humans, domestic and wild animals and is endemic in most parts of the India. Dog mediated rabies is more predominant than other forms of rabies and molecular epidemiology is poorly understood in both reservoir and susceptible hosts. In the present study, a total of 140 rabies suspected brain samples from different species of animals from different geographical regions of India were used. The samples were parallelly tested by direct fluorescent antibody test, reverse transcriptase PCR and real-time PCR. Thirty positive samples were subjected for partial nucleoprotein gene sequencing and phylogenetic analysis. On sequence and phylogenetic analysis, it was observed that all Indian rabies viruses belonged to classical rabies virus of genotype 1 of Lyssavirus and formed two distinct groups. The majority of isolates were in group-1 and are closely related to arctic/arctic like lineage, whereas group-II isolated are closely related to cosmopolitan lineage. These results indicated there is simultaneous existence of two distinct lineages of rabies viruses in Indian subcontinent. Further whole genome studies are needed for better understanding of molecular epidemiology of rabies virus circulating in animals for control and prevention of rabies in India.
Not Available
 
Date 2019-05-25T03:47:18Z
2019-05-25T03:47:18Z
2018-07-17
 
Type Research Paper
 
Identifier Not Available
2347-3517
http://krishi.icar.gov.in/jspui/handle/123456789/19850
 
Language English
 
Relation Not Available;
 
Publisher Springer publishers