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Molecular evidence and phylogenetic analysis of orf virus isolates from outbreaks in Tripura state of North-East India

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Title Molecular evidence and phylogenetic analysis of orf virus isolates from outbreaks in Tripura state of North-East India
Not Available
 
Creator Venkatesan G
De A
Arya S
Kumar A
Muthuchelvan D
Debnath BC
Dutta TK
Hemadri D
Pandey AB
 
Subject B2L
Contagious ecthyma
Diagnostics
Epidemiology
Phylogeny
Vaccines
 
Description Not Available
This study describes the first confirmed report of contagious ecthyma in Black Bengal goats from Tripura state, a North-Eastern state of India situated at the Indo-Bangladesh border. Outbreaks were characterized by the high rates of morbidity (58-67%), low mortality (8-10%) and case fatality (11-15%). The etiology of the outbreaks was confirmed as orf virus (ORFV) by standard virological/serological and molecular techniques including sequence analysis of B2L, a major envelop protein gene of genus Parapoxvirus. Sequence and phylogenetic analysis based on B2L gene of ORFV isolates from Tripura revealed that they were closely related to each other and also to other Indian isolates, in particular to ORFV-Shahjahanpur 82/04 isolate from North India. They revealed several specific nucleotide/amino acid substitutions, namely G299A (G100D), G660A, C705T, C795T (N267D) and G872A (R291H) which may be of notable epidemiological significance. This report necessitates the systematic investigation of orf outbreaks in susceptible populations including wild species particularly at transboundary regions by use of rapid diagnostics to control the infection by deploying an effective vaccine/therapeutics and better managemental practices.
Not Available
 
Date 2019-05-27T06:30:59Z
2019-05-27T06:30:59Z
2018-03-22
 
Type Research Paper
 
Identifier Not Available
2347-3517
http://krishi.icar.gov.in/jspui/handle/123456789/19901
 
Language English
 
Relation Not Available;
 
Publisher Indian Virological Society