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Ellagic and ferulic acids protect arsenic-induced male reproductive toxicity via regulating Nfe2l2, Ppargc1a and StAR expressions in testis

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Title Ellagic and ferulic acids protect arsenic-induced male reproductive toxicity via regulating Nfe2l2, Ppargc1a and StAR expressions in testis
Not Available
 
Creator Guvvala PR,
Ravindra JP,
Selvaraju S,
Arangasamy A,
Venkata Krishnaiah M.
 
Subject Arsenic
Ellagic acid
Ferulic acid
Oxidative stress
Sperm
Testes
 
Description Not Available
Arsenic (As) - induced oxidative stress causes male reproductive toxicity apart from its other generalized systemic effects. Some phytochemicals through their antioxidant properties might help to overcome such toxic effects. The aim of the study was to elucidate the protective role of the selected phytochemicals, ellagic and ferulic acids against the As-induced reproductive toxicity. Forty two healthy male Swiss albino mice were randomly assigned to six groups (each @ n = 7). Group A served as the control, while group B received 200 ppm of As through drinking water. The group C and D mice were administered Per os (P.O) with 50 mg/kg BW of ellagic and ferulic acids, respectively on alternate days. Group E or F received 50 mg of ellagic or ferulic acid + 200 ppm of As for forty days. Ellagic and/ ferulic acid significantly reduced the accumulation of As, protein carbonylation (PC), lipid peroxidation (LPO) in addition to altering the antioxidant enzymes (CAT and SOD) activities, reduced glutathione (GSH) and total antioxidant capacity (TAC) in the testicular tissues. A significantly (p  80%, ALH > 2.5 μm) and testicular damage induced by the As were ameliorated (p 
 
Date 2019-11-15T07:04:16Z
2019-11-15T07:04:16Z
2018-11-28
 
Type Research Paper
 
Identifier Guvvala PR, Ravindra JP, Selvaraju S, Arangasamy A, Venkata Krishnaiah M. 2019. Ellagic and ferulic acids protect arsenic-induced male reproductive toxicity via regulating Nfe2l2, Ppargc1a and StAR expressions in testis. Toxicology, 413:1-12.
0300-483X
http://krishi.icar.gov.in/jspui/handle/123456789/24762
 
Language English
 
Relation Not Available;
 
Publisher Elsevier