Ellagic and ferulic acids protect arsenic-induced male reproductive toxicity via regulating Nfe2l2, Ppargc1a and StAR expressions in testis
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Title |
Ellagic and ferulic acids protect arsenic-induced male reproductive toxicity via regulating Nfe2l2, Ppargc1a and StAR expressions in testis
Not Available |
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Creator |
Guvvala PR,
Ravindra JP, Selvaraju S, Arangasamy A, Venkata Krishnaiah M. |
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Subject |
Arsenic
Ellagic acid Ferulic acid Oxidative stress Sperm Testes |
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Description |
Not Available
Arsenic (As) - induced oxidative stress causes male reproductive toxicity apart from its other generalized systemic effects. Some phytochemicals through their antioxidant properties might help to overcome such toxic effects. The aim of the study was to elucidate the protective role of the selected phytochemicals, ellagic and ferulic acids against the As-induced reproductive toxicity. Forty two healthy male Swiss albino mice were randomly assigned to six groups (each @ n = 7). Group A served as the control, while group B received 200 ppm of As through drinking water. The group C and D mice were administered Per os (P.O) with 50 mg/kg BW of ellagic and ferulic acids, respectively on alternate days. Group E or F received 50 mg of ellagic or ferulic acid + 200 ppm of As for forty days. Ellagic and/ ferulic acid significantly reduced the accumulation of As, protein carbonylation (PC), lipid peroxidation (LPO) in addition to altering the antioxidant enzymes (CAT and SOD) activities, reduced glutathione (GSH) and total antioxidant capacity (TAC) in the testicular tissues. A significantly (p 80%, ALH > 2.5 μm) and testicular damage induced by the As were ameliorated (p |
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Date |
2019-11-15T07:04:16Z
2019-11-15T07:04:16Z 2018-11-28 |
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Type |
Research Paper
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Identifier |
Guvvala PR, Ravindra JP, Selvaraju S, Arangasamy A, Venkata Krishnaiah M. 2019. Ellagic and ferulic acids protect arsenic-induced male reproductive toxicity via regulating Nfe2l2, Ppargc1a and StAR expressions in testis. Toxicology, 413:1-12.
0300-483X http://krishi.icar.gov.in/jspui/handle/123456789/24762 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Elsevier
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