Alternate vaccine strain selection in the wake of emerging foot-and-mouth disease virus serotype A antigenic variants in India
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Title |
Alternate vaccine strain selection in the wake of emerging foot-and-mouth disease virus serotype A antigenic variants in India
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Creator |
Jajati Keshari Mohapatra, Biswajit Das, Manoranjan Rout, B.P.Sreenivasa, Saravanan Subramaniam, Aniket Sanyal, Bramhadev Pattnaik
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Subject |
IndiaFMD virus serotype AAlternate vaccine strain selectionVNT
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Description |
Not Available
‘National foot-and-mouth disease (FMD) control programme’ is being implemented in India and therefore predicting vaccine match is a key surveillance task. Recently, a considerable proportion of field viruses (75.6%) showed antigenic drift from the existing serotype A vaccine strain A IND 40/2000 necessitating search for an alternate strain. Here, antigenic relationship (‘r1’ value) of 87 field viruses with each of the 8 candidate strains was estimated by virus neutralization test. A IND 27/2011 strain emerged to be the one with the widest spectrum of antigenic coverage showing ‘r1’ value of more than 0.3 with 81.6% of field strains. It achieved a reasonably high titre of log10 7.5 TCID50/ml in BHK-21 suspension cell which was accompanied by positive charge gaining substitutions (E82–K and E131–K in VP2) thought to have adaptive significance. However, potency trial remains to be conducted before A IND 27/2011 finds a place in the vaccine formulation. Not Available |
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Date |
2019-11-19T05:21:16Z
2019-11-19T05:21:16Z 2018-05-31 |
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Type |
Research Paper
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Identifier |
Not Available
Not Available http://krishi.icar.gov.in/jspui/handle/123456789/24869 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Elsevier
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