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Alternate vaccine strain selection in the wake of emerging foot-and-mouth disease virus serotype A antigenic variants in India

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Title Alternate vaccine strain selection in the wake of emerging foot-and-mouth disease virus serotype A antigenic variants in India
 
Creator Jajati Keshari Mohapatra, Biswajit Das, Manoranjan Rout, B.P.Sreenivasa, Saravanan Subramaniam, Aniket Sanyal, Bramhadev Pattnaik
 
Subject IndiaFMD virus serotype AAlternate vaccine strain selectionVNT
 
Description Not Available
‘National foot-and-mouth disease (FMD) control programme’ is being implemented in India and therefore predicting vaccine match is a key surveillance task. Recently, a considerable proportion of field viruses (75.6%) showed antigenic drift from the existing serotype A vaccine strain A IND 40/2000 necessitating search for an alternate strain. Here, antigenic relationship (‘r1’ value) of 87 field viruses with each of the 8 candidate strains was estimated by virus neutralization test. A IND 27/2011 strain emerged to be the one with the widest spectrum of antigenic coverage showing ‘r1’ value of more than 0.3 with 81.6% of field strains. It achieved a reasonably high titre of log10 7.5 TCID50/ml in BHK-21 suspension cell which was accompanied by positive charge gaining substitutions (E82–K and E131–K in VP2) thought to have adaptive significance. However, potency trial remains to be conducted before A IND 27/2011 finds a place in the vaccine formulation.
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Date 2019-11-19T05:21:16Z
2019-11-19T05:21:16Z
2018-05-31
 
Type Research Paper
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/24869
 
Language English
 
Relation Not Available;
 
Publisher Elsevier