Record Details

Sodium alginate and gum acacia hydrogels of ZnO nanoparticles show wound healing effect on fibroblast cells

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title Sodium alginate and gum acacia hydrogels of ZnO nanoparticles show wound healing effect on fibroblast cells
Not Available
 
Creator R.Raguvarana, Balvinder K.Manuja, Meenu Chopra, Rajesh Thakur,TarunaAnand, Anu Kalia, Anju Manuja
 
Subject Zinc oxideNanoparticlesHydrogelsFibroblast cellsSodium alginateGum acacia
 
Description Not Available
An ideal biomaterial for wound dressing applications should possess antibacterial and anti-inflammatory properties without any toxicity to the host cells while providing the maximum healing activity. Zinc oxide nanoparticles (ZnONPs) possess antimicrobial activity and enhance wound healing, but the questions regarding their safety arise before application to the biological systems. We synthesized ZnONPs-loaded-sodium alginate-gum acacia hydrogels (SAGA-ZnONPs) by cross linking hydroxyl groups of the polymers sodium alginate and gum acacia with the aldehyde group of gluteradehyde. Here, we report the wound healing properties of sodium alginate/gum acacia/ZnONPs, circumventing the toxicity of ZnONPs simultaneously. We demonstrated the concentration-dependent zones of inhibition in treated cultures of Pseudomonas aerigunosa and Bacillus cereus and biocompatability on peripheral blood mononuclear/fibroblast cells. SAGA-ZnONPs hydrogels showed a healing effect at a low concentration of ZnONPs using sheep fibroblast cells. Our findings suggest that high concentrations of ZnONPs were toxic to cells but SAGA-ZnONPs hydrogels significantly reduced the toxicity and preserved the beneficial antibacterial and healing effect.
Not Available
 
Date 2020-07-31T06:51:24Z
2020-07-31T06:51:24Z
2017-03-01
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/38671
 
Language English
 
Relation Not Available;
 
Publisher Elsevier