Record Details

Cytotoxicity and genotoxicity of a trypanocidal drug quinapyramine sulfate loaded-sodium alginate nanoparticles in mammalian cells

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title Cytotoxicity and genotoxicity of a trypanocidal drug quinapyramine sulfate loaded-sodium alginate nanoparticles in mammalian cells
Not Available
 
Creator AnjuManujaaBalvinderKumaraMeenuChopraaAnshuBajajaRajenderKumaraNeerajDilbaghibSandeepKumarbSandeepSinghabT.RiyeshaSuresh C.Yadava
 
Subject TrypanosomaNanomedicineGenotoxicityCytotoxicityOxidative stress
 
Description Not Available
We synthesized quinapyramine sulfate loaded-sodium alginate nanoparticles (QS-NPs) to reduce undesirable toxic effects of QS against the parasite Trypanosoma evansi, a causative agent of trypanosomosis. To determine the safety of the formulated nanoparticles, biocompatibility of QS-NPs was determined using Vero, Hela cell lines and horse erythrocytes in a dose-dependent manner. Our experiments unveiled a concentration-dependent safety/cytotoxicity (metabolic activity), genotoxicity (DNA damage, chromosomal aberrations), production of reactive oxygen species and hemolysis in QS-NPs treated cells. Annexin-V propidium iodide (PI) staining showed no massive apoptosis or necrosis. However, at very high doses (more than 300 times than the effective doses), we observed more toxicity in QS-NPs treated cells as compared to QS treated cells. QS-NPs were safe at effective trypanocidal doses and even at doses several times higher than the effective dose.
Not Available
 
Date 2020-07-31T06:52:15Z
2020-07-31T06:52:15Z
2016-07-01
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/38674
 
Language English
 
Relation Not Available;
 
Publisher Elsevier