Record Details

production and preclinical assessment of camelid immunoglobulins against Echis sochureki venom from desert of rajasthan, india

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title production and preclinical assessment of camelid immunoglobulins against Echis sochureki venom from desert of rajasthan, india
Not Available
 
Creator Tanwar P. D
Ghorui SK
Kochar SK
Singh R
Patil NV
 
Subject Camelid antivenom
Echis c. sochureki
Lethal dose
Preclinical study
 
Description Not Available
Snakebite is a significant cause of death and disability in subsistent farming populations of rural India. Antivenom is the most effective treatment of envenoming and is manufactured from IgG of venom-immunised horses. Because of complex fiscal reasons, the production, testing and delivery of antivenoms designed to treat envenoming by the most medically-important snakes in the region has been questioned time to time. In this study, we report successful immunisation of dromedaries (Camelus dromedarius) against the venom of Indian saw-scaled Viper- Echis carinatus sochureki. This study assessed the specificity and potential of camels immunised with venom of medically most important snake of Western India, the saw-scaled viper (Echis c. sochureki). Using WHO standard pre-clinical in vivo tests the neutralisation of the venom responsible for the lethal, haemorrhagic, coagulant and local necrotizing activities were measured, since these are the most significant effects that characterize envenoming by this species. The anti-venom was found significantly effective in the neutralisation of all these effects tested and thus, revealed further an immunological perspective, that camel IgG anti-venom (monospecific) would be as efficacious as specific equine anti-venoms or even of better choice in treating snake specific envenoming.
Not Available
 
Date 2020-03-13T06:35:03Z
2020-03-13T06:35:03Z
2017-01-01
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/33797
 
Language English
 
Relation Not Available;
 
Publisher Not Available