Record Details

In£uence of Diet Type and Pretreatment Fasting on the Disposition Kinetics of Albendazole in Sheep

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title In£uence of Diet Type and Pretreatment Fasting on the Disposition Kinetics of Albendazole in Sheep
Not Available
 
Creator D. Singh, P.K. Sanyal, C.P. Swarnkar, F.A. Khan and P.S.K. Bhagwan
 
Subject albendazole, diet, fasting, green fodder, pharmacokinetics, sheep
 
Description Not Available
The in£uence of the quality and quantity of diets on the disposition kinetics of albendazole were studied
in sheep in two di¡erent experiments. The plasma concentration pro¢les of albendazole sulphoxide and
albendazole sulphone were measured following intraruminal administration of albendazole at 5.0 mg/
kg body weight in weaner sheep o¡ered three di¡erent diets: 100% green Sorghum spp., 100% dry
mature Cenchrus ciliaris hay and a 50:50 mix of these two diets. The peak plasma concentrations and
the availability of the albendazole metabolites, as measured by the area under the concentration^time
curve, were signi¢cantly higher (p50.01) in the animals o¡ered exclusively dry fodder compared to
other diets. Changing the diet from dry to green fodder resulted in a signi¢cantly lower systemic
availability of the drug metabolites. It is suggested that a decreased transit time of the digesta in the
bowel on the green diet, with its high water content, limited the systemic availability of the drug by
reducing the time available for gastrointestinal absorption.
An experiment on the in£uence of di¡erent levels of pretreatment fasting on the pharmacokinetics
of albendazole revealed signi¢cantly higher (p50.05) plasma concentrations of the anthelmintically
active sulphoxide metabolite from 12 h onwards following administration of the drug in animals
subjected to 24 h of pretreatment fasting compared to other groups with pretreatment fasting of 8, 12 or
18 h. The area under the concentration^time curve and the minimum residence time of the drug
metabolites were signi¢cantly greater (p50.05) in animals that had been fasted for 24 h. It is suggested
that fasting induces a decrease in the £ow of digesta through the gastrointestinal tract of ruminants and
prolongs the duration of dissolution of the drug, resulting in enhancement of the absorption of
albendazole and of the systemic availability of its metabolites.
ICAR and NDDB
 
Date 2020-09-09T06:43:32Z
2020-09-09T06:43:32Z
1999-04-01
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/41070
 
Language English
 
Relation Not Available;
 
Publisher Kluwer Academic Publishers