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Blended nanostructured degradable mesh with endometrial mesenchymal stem cells promotes tissue integration and anti-inflammatory response in vivo for pelvic floor application

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Title Blended nanostructured degradable mesh with endometrial mesenchymal stem cells promotes tissue integration and anti-inflammatory response in vivo for pelvic floor application
Not Available
 
Creator S. Mukherjee
S. Darzi
A. Rosamilia
V. Kadam
Y. Truong
J. A. Werkmeister,
C. E. Gargett
 
Subject Electrospinning
Mesenchymal Stem Cells
Tissue Engineering
Foreign Body
Response
Pelvic Organ Prolapse
iomaterials
 
Description Not Available
The current urogynaecological clinical meshes trigger unfavourable foreign body response
which leads to graft failure in the long term. To overcome the present challenge we applied a
tissue engineering strategy using endometrial SUSD2+ Mesenchymal stem cells (eMSCs) with
high regenerative properties. This study delves deeper into foreign body response to SUSD2+
eMSC based degradable PLACL/Gelatin nanofiber meshes using a mice model targeted at
understanding immunomodulation and mesh integration in the long term. Delivery of cells with
nanofiber mesh provides a unique topography that enables entrapment of therapeutic cells for
upto 6 weeks that promotes substantial cellular infiltration of host anti-inflammatory
macrophages. As a result, degradation rate and tissue integration are highly impacted by
eMSCs, revealing an unexpected level of implant integration over 6 weeks in vivo. From a
clinical perspective, such immunomodulation may aid in overcoming the current challenges
and provide an alternative to an unmet women’s urogynaecological health need.
National Health and Medical Research Council (NHMRC), Australia
CSIRO, Clayton Australia
 
Date 2020-09-10T03:19:05Z
2020-09-10T03:19:05Z
2018-12-04
 
Type Research Paper
 
Identifier Mukherjee, S., Darzi, S., Rosamilia, A., Kadam, V., Truong, Y., Werkmeister, J. A., & Gargett, C. E. (2018). Blended nanostructured degradable mesh with endometrial mesenchymal stem cells promotes tissue integration and anti-inflammatory response in vivo for pelvic floor application. Biomacromolecules, 20(1), 454-468.
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/41104
 
Language English
 
Relation Not Available;
 
Publisher ACS Publications