Evolutionary dynamics of foot-and-mouth disease virus O/ME-SA/Ind2001 lineage.
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Title |
Evolutionary dynamics of foot-and-mouth disease virus O/ME-SA/Ind2001 lineage.
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Creator |
Subramaniam S, Mohapatra JK, Sharma GK, Biswal JK, Ranjan R, Rout M, Das B, Dash BB, Sanyal A, Pattnaik B
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Subject |
Foot-and-mouth disease; Ind2001 lineage; Serotype O
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Description |
Not Available
Foot-and-mouth disease (FMD) virus serotype O Ind2001 lineage within the Middle East-South Asia topotype is the major cause of recent FMD incidences in India. A sub-lineage of Ind2001 caused severe outbreaks in the southern region of the country during 2013 and also reported for the first time from Libya. In this study, we conducted a detailed evolutionary analysis of Ind2001 lineage. Phylogenetic analysis of Ind2001 lineage based on maximum likelihood method revealed two major splits and three sub-lineages. The mean nucleotide substitution rate for this lineage was calculated to be 6.338×10(-3)substitutions/site/year (s/s/y), which is similar to those of PanAsian sub-lineages. Evolutionary time scale analysis indicated that the Ind2001 lineage might have originated in 1989. The sub-lineage Ind2001d that caused 2013 outbreaks seems to be relatively more divergent genetically from other Ind2001 sub-lineages. Seven codons in the VP1 region of Ind2001 were found to be under positive selection. Four out of 24 recent Ind2001 strains tested in 2D-MNT had antigenic relationship value of Not Available |
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Date |
2021-02-09T05:40:47Z
2021-02-09T05:40:47Z 2015-05-27 |
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Type |
Research Paper
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Identifier |
Subramaniam S, Mohapatra JK, Sharma GK, Biswal JK, Ranjan R, Rout M, Das B, Dash BB, Sanyal A, Pattnaik B (2015) Evolutionary dynamics of foot-and-mouth disease virus O/ME-SA/Ind2001 lineage. Vet Microbiol. 178(3-4):181-9
Not Available http://krishi.icar.gov.in/jspui/handle/123456789/45296 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Elsevier
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