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Leaf Extract of Aerva javanica Suppresses Excessive Growth of Granulation Tissue in Horses

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Title Leaf Extract of Aerva javanica Suppresses Excessive Growth of Granulation Tissue in Horses
Not Available
 
Creator Ramesh Kumar Dedar
Naveen Kumar
Shirish D. Narnaware
Bhupendra Nath Tripathi
 
Subject Aerva javanica
Excessive growth of granulation tissue
Horse
Kaempferol
Keloid Proud flesh
 
Description Not Available
Wound healing in horses is complicated by the excessive growth of granulation tissue, commonly known as proud flesh and is similar to keloids in human beings. At present, there is no satisfactory treatment for proud flesh in horses. In this study, we, for the first time, demonstrated that leaf extract of Aerva javanica suppresses excessive growth of granulation tissue in horses. Many plant flavonoids are claimed to have antiproliferative properties. Kaempferol is a natural flavonoid containing 3-hydroxy flavone backbone found in many plants in its aglycone form and attached with various sugars. Ecdysteroids are steroidal analogs of invertebrate steroidal hormones found in plants. Both flavonoids and ecdysteroids accumulate more in plants during abiotic stress. We hypothesized that Aerva javanica may have high levels of ecdysteroids and kaempferols for surviving in stressful conditions of desert. Those kaempferols may suppress the growth of granulation tissue by their antiangiogenesis property. Ecdysteroids may control the larvae of habronema if associated with proud flesh. Extract was prepared using solvent-based fractionation and silica gel column flash chromatography. Application of the leaf extract in horses suppressed growth of granulation tissue along with restoration of normal skin function. Various purification steps and mass spectrometry were used to identify the active components in the study.
Not Available
 
Date 2021-06-17T06:29:45Z
2021-06-17T06:29:45Z
2020-10-01
 
Type Article
 
Identifier Not Available
0737-0806
http://krishi.icar.gov.in/jspui/handle/123456789/47317
 
Language English
 
Relation Not Available;
 
Publisher Elsevier