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Epididymosomes: A potential male fertility influencer

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Title Epididymosomes: A potential male fertility influencer
Not Available
 
Creator Nilendu Paul, Thirumala Rao Talluri, Pradeep Nag and Arumugam Kumaresan
 
Subject epididymis, epididymosomes, male fertility, sperm maturation, sperm proteins
 
Description During transit and storage in epididymis, spermatozoa undergo final maturation, acquire motility, functional competence and the ability to fertilise an oocyte. Epididymal
secretions contain a complex biochemical milieu of diverse inorganic ions, proteins,
metabolites and other molecules. Since it is believed that spermatozoa are translationally silent, proteins appearing in them are thought to be synthesised elsewhere,
including epididymis, and then incorporated to the cells. One of the important mechanisms suggested to be involved in transfer of epididymal secretions to spermatozoa
is through exosomes called epididymosomes. Epididymosomes released from the
epididymal epithelium contain proteins, noncoding RNAs and distinct set of lipids
that are transferred to spermatozoa while they pass through the different epididymal regions. Owing to the importance of these molecules for sperm maturation and
fertilising ability, research on epididymosomes has gained increasing attention during
the last decade. This review is focused on epididymosomes, with emphasis on recent
advances in the understanding of mechanisms of epididymosomal cargo transfer to
spermatozoa and potential roles of epididymosomes in sperm function and beyond.
Possibilities of utilising the molecular signatures of epididymosomes as a tool for
male fertility assessment are also discussed
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Date 2021-07-15T07:10:27Z
2021-07-15T07:10:27Z
2021-06-04
 
Type Review Paper
 
Identifier Paul, N., Talluri, T. R., Nag, P., & Kumaresan, A. (2021). Epididymosomes: A potential male fertility influencer. Andrologia, 00, e14155. https://doi. org/10.1111/and.14155
1439-0272
http://krishi.icar.gov.in/jspui/handle/123456789/48086
 
Language English
 
Relation Not Available;
 
Publisher Andrologia