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Alternate vaccine strain selection in the wake of emerging foot-and-mouth disease virus serotype A antigenic variants in India

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Title Alternate vaccine strain selection in the wake of emerging foot-and-mouth disease virus serotype A antigenic variants in India
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Creator Jajati Keshari Mohapatra
Biswajit Das
Manoranjan Rout
B P Sreenivasa
Saravanan Subramaniam
Aniket Sanyal
Bramhadev Pattnaik
 
Subject Alternate vaccine strain selection, FMD virus serotype A, India, VNT
 
Description Not Available
National foot-and-mouth disease (FMD) control programme’ is being implemented in India and therefore predicting vaccine match is a key surveillance task. Recently, a considerable proportion of field viruses (75.6%) showed antigenic drift from the existing serotype A vaccine strain A IND 40/2000 necessitating search for an alternate strain. Here, antigenic relationship (‘r1’ value) of 87 field viruses with each of the 8 candidate strains was estimated by virus neutralization test. A IND 27/2011 strain emerged to be the one with the widest spectrum of antigenic coverage showing ‘r1’ value of more than 0.3 with 81.6% of field strains. It achieved a reasonably high titre of log10 7.5 TCID50/ml in BHK-21 suspension cell which was accompanied by positive charge gaining substitutions (E82–K and E131–K in VP2) thought to have adaptive significance. However, potency trial remains to be conducted before A IND 27/2011 finds a place in the vaccine formulation.
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Date 2021-08-01T12:05:07Z
2021-08-01T12:05:07Z
2018-05-31
 
Type Research Paper
 
Identifier Mohapatra JK, Das B, Rout M, Sreenivasa BP, Subramaniam S, Sanyal A, Pattnaik B. Alternate vaccine strain selection in the wake of emerging foot-and-mouth disease virus serotype A antigenic variants in India. Vaccine. 2018 May 31;36(23):3191-3194. doi: 10.1016/j.vaccine.2018.04.090. Epub 2018 May 4. PMID: 29735325.
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http://krishi.icar.gov.in/jspui/handle/123456789/51834
 
Language English
 
Relation Not Available;
 
Publisher Elsevier