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Experimental evidence for competitive growth advantage of genotype VII over VI: implications for foot-and-mouth disease virus serotype A genotype turnover in nature

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Title Experimental evidence for competitive growth advantage of genotype VII over VI: implications for foot-and-mouth disease virus serotype A genotype turnover in nature
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Creator J K Mohapatra
S Subramaniam
N K Singh
A Sanyal
B Pattnaik
 
Subject FMD virus, Genotype evolution, In vitro competition experiment
 
Description Not Available
In India, systematic genotype replacement has been observed for serotype A foot-and-mouth disease virus. After a decade of co-circulation of genotypes VI and VII, genotype VII emerged as the single dominant genotype since 2001. To derive possible explanations for such epochal evolution dynamics, in vitro intergenotype growth competition experiments involving both co- and superinfection regimes were conducted. Coinfection of BHK-21 cells demonstrated abrupt loss in the genotype VI viral load with commensurate increase in the load of genotype VII as measured by the genotype differentiating ELISA, RT-PCR and real-time RT-PCR. The superinfection dynamics was shaped by temporal spacing of infection, where the invading genotype VII took more number of passages than coinfection to eventually overtake the resident genotype VI. It was speculated that such superior replicative fitness of genotype VII could have been a possible factor for the ultimate dominance of genotype VII in nature.
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Date 2021-08-05T04:47:14Z
2021-08-05T04:47:14Z
2012-04-01
 
Type Research Paper
 
Identifier Mohapatra JK, Subramaniam S, Singh NK, Sanyal A, Pattnaik B. Experimental evidence for competitive growth advantage of genotype VII over VI: implications for foot-and-mouth disease virus serotype A genotype turnover in nature. Res Vet Sci. 2012 Apr;92(2):317-9. doi: 10.1016/j.rvsc.2011.01.030. Epub 2011 Feb 19. PMID: 21338995.
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http://krishi.icar.gov.in/jspui/handle/123456789/53144
 
Language English
 
Relation Not Available;
 
Publisher Elsevier