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Phylogenetic analysis of 3C protease (3C(pro)) coding region of Foot-and-mouth disease virus type A

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Title Phylogenetic analysis of 3C protease (3C(pro)) coding region of Foot-and-mouth disease virus type A
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Creator J K Mohapatra
P Priyadarshini
L Pandey
S Subramaniam
D Hemadri
A Sanyal
B Pattnaik
 
Subject Not Available
 
Description Not Available
Nucleotide sequence analysis of the 3C protease (3C(pro)) region of Foot-and-mouth disease virus type A (FMDV-A) isolates from India has revealed incongruous phylogenetic grouping between 3C(pro) and VP1 region possibly due to the genetic recombination or independent evolution of non-structural and structural protein coding regions. Similar to the VP1 region, the emerging VP3(59)-deletion group maintained its genetic distinctiveness at 3C(pro) region and was found to be diverging with time. Two lineage specific signature aa residues were detected for the deletion group in proof of lineage specific drift or selection events. 3C(pro) region exhibited high degree of conservation as evident from low dN/dS ratio (0.036) and percentage of variable aa positions (20%). A transmembrane domain from aa 27 to 44 could be predicted that possibly anchors 3C to intracellular membranes for better interaction with RNA replication complex. On the basis of sequence conservation, the likelihood that the region aa 121-150 was carrying a vaccine exploitable T-cell epitope was very high.
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Date 2021-08-12T04:44:40Z
2021-08-12T04:44:40Z
2009-03-01
 
Type Research Paper
 
Identifier Mohapatra JK, Priyadarshini P, Pandey L, Subramaniam S, Hemadri D, Sanyal A, Pattnaik B. Phylogenetic analysis of 3C protease (3C(pro)) coding region of Foot-and-mouth disease virus type A. Acta Virol. 2009;53(3):175-83. doi: 10.4149/av_2009_03_175. PMID: 19941399.
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http://krishi.icar.gov.in/jspui/handle/123456789/55153
 
Language English
 
Relation Not Available;
 
Publisher AEPress