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Seasonal alterations in the expression of inflammatory cytokines and cortisol concentrations in periparturient Sahiwal cows

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Title Seasonal alterations in the expression of inflammatory cytokines and cortisol concentrations in periparturient Sahiwal cows
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Creator Sonika Grewal, Anjali Aggarwal & Mohanned Naif Alhussien
 
Subject Heat stress; periparturient cows; PBMC; interleukins; TNF-α
 
Description Not Available
Heat stress during the transition period of dairy cows disturbs the
homeostasis of their physiology and ultimately their health and pro duction. Our objective was to study the seasonal variations of plasma
cortisol levels and the expression of inflammatory cytokines in the
peripheral blood mononuclear cells (PBMC) of 12 periparturient
Sahiwal cows. Blood samples were obtained at weekly intervals from
three weeks prepartum to three weeks postpartum during the winter
(Temperature–humidity index, THI = 59.7) and summer (THI = 81.5)
seasons. Gene expression study of pro-inflammatory (IL-1β, IL-6, and
TNF-α) and anti-inflammatory (IL-10) cytokines was done by RT-PCR
and plasma cortisol by sandwich ELISA. The plasma concentration of
cortisol and the relative mRNA expression of various inflammatory
cytokines in PBMC were higher (p< 0.01) in the summer compared to
winter season irrespective of the days of the transition period. Highest
levels of cortisol and greater expression of pro-inflammatory cytokines
were recorded on the day of calving in both seasons. Our study
showed a higher inflammatory response, immune disturbance and
greater levels of the stress hormone (cortisol) during the summer
season, particularly on the day of calving.
Not Available
 
Date 2021-08-02T08:22:09Z
2021-08-02T08:22:09Z
2019-09-01
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/52071
 
Language English
 
Relation Not Available;
 
Publisher Not Available