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Consumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th2 pathway.

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Title Consumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th2 pathway.
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Creator Haq, M.R, Kapila, R.* and Saliganti ,V.
 
Subject β-casomorphins
immune response
Th2 pathway
 
Description Not Available
β-Casomorphins are opioid like bioactive peptides released on digestion of β-casein of milk. In the present study in vivo impact of consumption of β-casomorphins (BCM-7/5) was evaluated on immune response of murine gut. The peptides were given to mice through oral intubation at a dose of 7.5 × 10−8 mol/day/animal for 15 days. Oral administration of both peptides individually increased (p < 0.01) phenotypic expression of inflammation associated molecules (MPO, MCP-1, IL-4 and histamine), humoral immune response (IgE, IgG, IgG1/IgG2a), infiltration of leucocytes in intestinal villi and mRNA expression of toll like receptors (TLR-2
and TLR-4) in mice gut. However, no changes in sIgA, IgA+ and goblet cell numbers were recorded. These results clearly indicate that consumption of β-casein derived peptides BCM7/5 induce inflammatory immune response in gut, most likely through Th2 pathway
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Date 2021-08-04T08:40:56Z
2021-08-04T08:40:56Z
2014
 
Type Research Paper
 
Identifier Haq, M.R, Kapila, R.* and Saliganti ,V. (2014) Consumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th2 pathway. Journal of Functional Foods 8: 150-160.
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/52922
 
Language English
 
Relation 8;
 
Publisher Elsevier