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Dietary intake of pearl millet based weaning food supplemented with iron and vitamin A enhances bioavailability of vitamin A in anemic rats

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Title Dietary intake of pearl millet based weaning food supplemented with iron and vitamin A enhances bioavailability of vitamin A in anemic rats
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Creator Manvesh Kumar Sihag, Vivek Sharma, Ankit Goyal, Sumit Arora, and Rajeev Kapila
 
Subject allergy, iron bioavailability, pearl millet, vitamin A bioavailability, weaning food
 
Description Not Available
The study was aimed to assess vitamin A bioavailability and allergenicity of pearl millet (Pennisetum glaucum) based weaning food (PMWF) fortified with iron and retinyl acetate in male Wistar albino rats. Animals (n = 64) were divided into Normal (NG) and Anemic (AG)
groups; further sub-divided into 4 sub-groups having 8 animals each receiving synthetic diet, commercial diet, iron fortified PMWF diet and iron (150.00 ± 0.73 ppm) plus retinyl acetate (393.00 ± 3.07 μg/100 g) fortified PMWF diet (Final diet). Results revealed that anemic sub-groups showed apparent digestibility coefficient (ADC) in the range of 69.5 ± 0.40–93.2 ± 0.79%, which was significantly (P < 0.01) higher than normal sub-groups (65.5 ± 0.62–84.6 ± 0.33%). In both groups, rats fed final diet presented significantly (P < 0.01) higher ADC (84.6 ± 0.33–93.2 ± 0.79%) than that of animals received iron fortified diet (69.0 ± 0.59–76.1 ± 1.02%), indicating higher bioavailability of vitamin A in final diet. Moreover, hepatic vitamin A replenished rapidly in anemic groups (1.79–27.8) when compared to normal rats (1.11–19.4 μg/g liver). Immunoglobulins IgG, IgE in blood serum and IgA in intestinal fluid ranged from 574 ± 6.48 to 603 ± 9.76 μg/ml, 287 ± 4.46 to 309 ± 5.70 ng/ml and 204 ± 10.33 to 255 ± 13.22 μg/ml, respectively. However, no significant (P > 0.05) difference was observed between the groups and/or subgroups, suggesting no allergic response of final diet. Stimulation index triggered by lipopolysaccharide (LPS) ranged from 1.22 ± 0.06 to 1.45 ± 0.09 μg ml1 in normal sub-groups and 1.16 ± 0.02 to 1.33 ± 0.03 μg ml1 in anemic sub-groups with no significant (P > 0.05) difference among them. Overall, it can be concluded that retinyl acetate could be an effective fortificant to improve the status of vitamin A in anemic models.
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Date 2021-08-25T11:07:00Z
2021-08-25T11:07:00Z
2019
 
Type Research Paper
 
Identifier Int J Vitam Nutr Res (2019), 1–11
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http://krishi.icar.gov.in/jspui/handle/123456789/60546
 
Language English
 
Relation Not Available;
 
Publisher SCI Journal