Genome assisted probiotic characterization and application of Bacillus velezensis ZBG17 as an alternative to antibiotic growth promoters in broiler chickens
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Title |
Genome assisted probiotic characterization and application of Bacillus velezensis ZBG17 as an alternative to antibiotic growth promoters in broiler chickens
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Creator |
R. Soni
H. Keharia A. Bose N. Pandit J. Doshi S. V. Rama Rao S.S. Paul M.V.L.N. Raju |
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Subject |
Bacillus velezensis ZBG17
Probiotic Broiler |
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Description |
Not Available
The present study describes genome annotation and phenotypic characterization of Bacillus velezensis ZBG17 and evaluation of its performance as antibiotic growth promoter substitute in broiler chickens. ZBG17 comprises 3.89 Mbp genome with GC content of 46.5%. ZBG17 could tolerate simulated gastrointestinal juices prevalent in the animal gut. Some adhesion-associated genomic features of ZBG17 supported the experimentally determined cell surface hydrophobicity and cell aggregation results. ZBG17 encoded multiple secondary metabolite gene clusters correlating with its broad-spectrum antibacterial activity. Interestingly, ZBG17 completely inhibited Salmonella enterica and Escherichia coli within 6 h and 8 h in liquid co-culture assay, respectively. ZBG17 genome analysis did not reveal any genetic determinant associated with reported safety hazards for use as a poultry direct-fed microbial. Dietary supplementation of ZBG17 significantly improved feed utilization efficiency and humoral immune response in broiler chickens, suggesting its prospective application as a direct-fed microbial in broiler chickens. Not Available Pathogen exclusion antimicrobials Direct fed microbials |
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Date |
2022-02-14T04:31:07Z
2022-02-14T04:31:07Z 2021-10-19 |
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Type |
Research Paper
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Identifier |
R Soni, H Keharia, A Bose, N Pandit, J Doshi, SVR Rao, SS Paul, M Raju.2021. Genome assisted probiotic characterization and application of Bacillus velezensis ZBG17 as an alternative to antibiotic growth promoters in broiler chickens.Genomics 113, 4061-4074
Not Available http://krishi.icar.gov.in/jspui/handle/123456789/69781 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Elsevier Inc
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