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Genome assisted probiotic characterization and application of Bacillus velezensis ZBG17 as an alternative to antibiotic growth promoters in broiler chickens

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Title Genome assisted probiotic characterization and application of Bacillus velezensis ZBG17 as an alternative to antibiotic growth promoters in broiler chickens
 
Creator R. Soni
H. Keharia
A. Bose
N. Pandit
J. Doshi
S. V. Rama Rao
S.S. Paul
M.V.L.N. Raju
 
Subject Bacillus velezensis ZBG17
Probiotic
Broiler
 
Description Not Available
The present study describes genome annotation and phenotypic characterization of Bacillus velezensis ZBG17 and
evaluation of its performance as antibiotic growth promoter substitute in broiler chickens. ZBG17 comprises 3.89
Mbp genome with GC content of 46.5%. ZBG17 could tolerate simulated gastrointestinal juices prevalent in the
animal gut. Some adhesion-associated genomic features of ZBG17 supported the experimentally determined cell
surface hydrophobicity and cell aggregation results. ZBG17 encoded multiple secondary metabolite gene clusters
correlating with its broad-spectrum antibacterial activity. Interestingly, ZBG17 completely inhibited Salmonella
enterica and Escherichia coli within 6 h and 8 h in liquid co-culture assay, respectively. ZBG17 genome analysis
did not reveal any genetic determinant associated with reported safety hazards for use as a poultry direct-fed
microbial. Dietary supplementation of ZBG17 significantly improved feed utilization efficiency and humoral
immune response in broiler chickens, suggesting its prospective application as a direct-fed microbial in broiler
chickens.
Not Available
Pathogen exclusion
antimicrobials
Direct fed microbials
 
Date 2022-02-14T04:31:07Z
2022-02-14T04:31:07Z
2021-10-19
 
Type Research Paper
 
Identifier R Soni, H Keharia, A Bose, N Pandit, J Doshi, SVR Rao, SS Paul, M Raju.2021. Genome assisted probiotic characterization and application of Bacillus velezensis ZBG17 as an alternative to antibiotic growth promoters in broiler chickens.Genomics 113, 4061-4074
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/69781
 
Language English
 
Relation Not Available;
 
Publisher Elsevier Inc