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Quinapyramine sulfate-loaded sodium alginate nanoparticles show enhanced trypanocidal activity

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Title Quinapyramine sulfate-loaded sodium alginate nanoparticles show enhanced trypanocidal activity
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Creator Anju Manuja, Sandeep Kumar, Neeraj Dilbaghi, Gaurav Bhanjana, Meenu Chopra, Harmanmeet Kaur, Rajender Kumar, Balvinder Kumar Manuja, Shailendra K Singh, Suresh C Yadav
 
Subject nanoparticles, quinapyramine sulfate, sodium alginate, Trypanosoma evansi
 
Description Not Available
Aim: To reduce the dose, toxic effects and to ensure sustained release of quinapyramine sulfate (QS), a highly effective drug against Trypanosoma evansi. Materials & methods: QS-loaded sodium alginate nanoparticles (QS-NPs) were formed by emulsion-crosslinking technology using dioctyl-sodium-sulfosuccinate and sodium alginate. The formulation was characterized for size, stability, morphology and functional groups by a zetasizer, scanning electron microscopy, atomic force microscopy, transmission electron microscopy and Fourier transform infrared spectroscopy. In vitro safety and toxicity studies were performed by metabolic assay in Vero cell lines, and in vivo efficacy was evaluated in mice. Results: QS-NPs were
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Date 2022-09-29T09:48:13Z
2022-09-29T09:48:13Z
2014-01-01
 
Type Research Paper
 
Identifier Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/74615
 
Language English
 
Relation Not Available;
 
Publisher Future Medicine Ltd