Quinapyramine sulfate-loaded sodium alginate nanoparticles show enhanced trypanocidal activity
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Title |
Quinapyramine sulfate-loaded sodium alginate nanoparticles show enhanced trypanocidal activity
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Creator |
Anju Manuja, Sandeep Kumar, Neeraj Dilbaghi, Gaurav Bhanjana, Meenu Chopra, Harmanmeet Kaur, Rajender Kumar, Balvinder K Manuja, Shailendra K Singh, Suresh C Yadav
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Subject |
Trypanosoma evansi; nanoparticle; quinapyramine sulfate; sodium alginate
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Description |
Not Available
Aim: To reduce the dose, toxic effects and to ensure sustained release of quinapyramine sulfate (QS), a highly effective drug against Trypanosoma evansi. Materials & methods: QS-loaded sodium alginate nanoparticles (QS-NPs) were formed by emulsion-crosslinking technology using dioctyl-sodiumsulfosuccinate and sodium alginate. The formulation was characterized for size, stability, morphology and functional groups by a zetasizer, scanning electron microscopy, atomic force microscopy, transmission electron microscopy and Fourier transform infrared spectroscopy. In vitro safety and toxicity studies were performed by metabolic assay in Vero cell lines, and in vivo efficacy was evaluated in mice. Results: QS-NPs were Not Available |
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Date |
2022-09-29T09:48:54Z
2022-09-29T09:48:54Z 2014-01-10 |
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Type |
Research Paper
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Identifier |
Not Available
Not Available http://krishi.icar.gov.in/jspui/handle/123456789/74617 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Future Medicine
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