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Quinapyramine sulfate-loaded sodium alginate nanoparticles show enhanced trypanocidal activity

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Title Quinapyramine sulfate-loaded sodium alginate nanoparticles show enhanced trypanocidal activity
Not Available
 
Creator Anju Manuja, Sandeep Kumar, Neeraj Dilbaghi, Gaurav Bhanjana, Meenu Chopra, Harmanmeet Kaur, Rajender Kumar, Balvinder K Manuja, Shailendra K Singh, Suresh C Yadav
 
Subject Trypanosoma evansi; nanoparticle; quinapyramine sulfate; sodium alginate
 
Description Not Available
Aim: To reduce the dose, toxic effects and to ensure sustained release of quinapyramine sulfate (QS), a
highly effective drug against Trypanosoma evansi. Materials & methods: QS-loaded sodium alginate
nanoparticles (QS-NPs) were formed by emulsion-crosslinking technology using dioctyl-sodiumsulfosuccinate
and sodium alginate. The formulation was characterized for size, stability, morphology and
functional groups by a zetasizer, scanning electron microscopy, atomic force microscopy, transmission
electron microscopy and Fourier transform infrared spectroscopy. In vitro safety and toxicity studies were
performed by metabolic assay in Vero cell lines, and in vivo efficacy was evaluated in mice. Results: QS-NPs
were
Not Available
 
Date 2022-09-29T09:48:54Z
2022-09-29T09:48:54Z
2014-01-10
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/74617
 
Language English
 
Relation Not Available;
 
Publisher Future Medicine