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Biocompatibility and Targeting Efficiency of Encapsulated Quinapyramine Sulfate-Loaded Chitosan-Mannitol Nanoparticles in a Rabbit Model of Surra

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Title Biocompatibility and Targeting Efficiency of Encapsulated Quinapyramine Sulfate-Loaded Chitosan-Mannitol Nanoparticles in a Rabbit Model of Surra
Not Available
 
Creator Anju Manuja, Balvinder Kumar, Rajender Kumar, Meenu Chopra, Neeraj Dilbaghi, Sandeep Kumar, Suresh C. Yadav
 
Subject quinapyramine sulfate, nanoparticles, polymer therapeutics, chitosan, mannitol, Trypanosoma evansi
 
Description Not Available
Quinapyramine sulfate (QS) produces trypanocidal effects against the
parasite Trypanosoma evansi but is often poorly tolerated and causes serious reactions
in animals. The encapsulation of QS in chitosan-mannitol to provide sustained
release would improve both the therapeutic effect of QS and the quality of life of
animals treated with this formulation. QS was encapsulated into a nanoformulation
prepared from chitosan, tripolyphosphate, and mannitol nanomatrix (ChQS-NPs).
ChQS-NPs were well ordered in shape, with nanoparticle size, as determined by
transmission electron microscopy and atomic force microscopy. Our research revealed
dose-dependent effects on biosafety and DNA damage in mammalian cells
treated with ChQS-NPs. ChQS-NPs were absolutely risk-free at effective as well as
many times higher doses against T. evansi. ChQS-NPs were effective in rabbits, as
they killed the parasites, relieving the animals from the clinical symptoms of the disease.
The extent of this protection was similar to that observed with the conventional
drug at higher dosages (5 mg QS/kg of body weight). ChQS-NPs are safe, nontoxic,
and more effective than QS and offer a promising alternative to drug delivery
against surra in animal models. ChQS-NPs may be useful for the treatment of surra
due to reduced dosages and frequency of administration.
Not Available
 
Date 2022-09-29T09:50:21Z
2022-09-29T09:50:21Z
2018-09-28
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/74625
 
Language English
 
Relation Not Available;
 
Publisher American Society for Microbiology