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Recent Development in Identification of Potential Novel Therapeutic Targets Against Trypanosomatids

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Title Recent Development in Identification of Potential Novel Therapeutic Targets Against Trypanosomatids
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Creator Rajender Kumar, Parvati Sharma, Deepak Kumar Gaur and Shikha Jain
 
Subject Chemotherapy, drug target, kinetoplastid, therapeutic target, Trypanosoma, trypanosomatid, trypanosomosis
 
Description Not Available
Trypanosomatids continue to cause suffering among human and wide range of animal population and have enormous health, social and economic impact. The present constraints in control of trypanosomosis are availability of limited number of effective drugs with narrow safety index, nonavailability of vaccines due to immune evasion mechanisms developed by the parasite and drug resistance problem. The kinetoplastids/ trypanosomatids possess unique kinetoplast DNA structure and express hundreds of membrane transport proteins that allow them to take up nutrients, establish ion gradients, efflux metabolites, translocate compounds from one intracellular compartment to another, and take up or export drugs. In this context, there is urgent need of application of innovative strategies for identification of novel therapeutic drug targets affecting metabolic pathways essential for survival of the parasites using modern molecular approaches (functional/genomics/ proteomics/bioinformatics). In this review we have discussed existing drugs in use for treatment and outline of emerging approaches in identification and evaluation of potential novel therapeutic targets against trypanosomatids.
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Date 2022-09-29T09:52:10Z
2022-09-29T09:52:10Z
2016-01-01
 
Type Review Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/74635
 
Language English
 
Relation Not Available;
 
Publisher Bentham Science