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In silico screening and validation of KPHS_00890 protein of Klebsiella pneumoniae proteome: An application to bacterial resistance and pathogenesis.

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Title In silico screening and validation of KPHS_00890 protein of Klebsiella pneumoniae proteome: An application to bacterial resistance and pathogenesis.
Not Available
 
Creator Kendaganna PH
Shivamallu C
Shruthi G
Chitagudigi MN
Pradeep S
Karunakar P
Raghavendra AG
Patil SS
Syed A
Elgorban AM
Bahkali AH
Veerapur R
Kollur SP
 
Subject Molecular docking
Homology modeling
Phylogenetic tree
5′-nucleotidase
Klebsiella pneumoniae
Multiple sequence alignment
 
Description Not Available
Introduction: Nosocomial infections are a notorious subset of infectious diseases, varying between 10% and 20% prevalence worldwide. The infections are concomitant with various treatment complications, multiple-drug resistance, and a high degree of virulence. Klebsiella pneumoniae is a gram-negative bacteria of nosocomial importance. Objectives: Our current study is gauged to reason and understand why, despite treatment with cutting-edge medicines and technology, the K. pneumoniae remains elusive. Methods: Using various in silico tools, the KPHS_00890 hypothetical protein of K. pneumoniae subsp. pneumoniae HS11286 was identified and annotated. Results: A thorough investigation revealed that KPHS_00890 hypothetical protein is a bifunctional 5′-nucleotidase, an enzyme catalyzing the degradation of nucleotides to nucleosides. Conclusions: Scrutiny and review of the 5′-nucleotidase function across various species ascertained its pertinent role in immune evasion, by suppressing inflammatory responses. Thus, having identified the KPHS_00890 hypothetical protein of K. pneumoniae subsp. pneumoniae HS11286 as a 5′-nucleotidase, we propose that it may be involved in an immune evasion strategy during infection pathogenesis.
Not Available
 
Date 2022-04-18T09:27:15Z
2022-04-18T09:27:15Z
2021-07-06
 
Type Research Paper
 
Identifier Kendaganna PH, Shivamallu C, Shruthi G, Chitagudigi MN, Pradeep S, Karunakar P, Raghavendra AG, Patil SS, Syed A, Elgorban AM, Bahkali AH, Veerapur R. and Kollur, SP (2021). In silico screening and validation of KPHS_00890 protein of Klebsiella pneumoniae proteome: An application to bacterial resistance and pathogenesis. Journal of King Saud University Sciences, 33: 101537. https://doi.org/10.1016/j.jksus.2021.101537
1018-3647
http://krishi.icar.gov.in/jspui/handle/123456789/71578
 
Language English
 
Relation Not Available;
 
Publisher Elsevier Publishing