Pulmonary inflammatory response to influenza virus infection in pigs is regulated by DAP12 and macrophage M1 and M2 phenotypes
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Title |
Pulmonary inflammatory response to influenza virus infection in pigs is regulated by DAP12 and macrophage M1 and M2 phenotypes
Not Available |
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Creator |
Hiremath J
Renu S Tabynov K Renukaradhya GJ |
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Subject |
Influenza A virus
DAP12 M1 and M2 macrophages Pigs |
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Description |
Not Available
We delineated the expression of DAP12 (DNAX-Activating Protein) and its associated receptors, TREM-1, TREM-2 and MDL-1 in pig alveolar monocyte/macrophages (AMM) that have attained M1 or M2 phenotypes. Pig AMM stimulated in vitro with IFN-γ and IL-4 induced the expression of M1 (TNFα and iNOS) and M2 (ARG1 and no MMR) phenotypic markers, respectively. In influenza virus infected pigs at seven days post-infection, in addition to substantial modulations in the M1 and M2 markers expression, DAP12, TREM-1 and MDL-1 were downregulated in AMM. Thus, DAP12 signaling promoted the anti-inflammatory pathway in AMM of influenza virus infected pigs. Not Available |
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Date |
2021-04-22T03:56:22Z
2021-04-22T03:56:22Z 2020-02-21 |
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Type |
Research Paper
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Identifier |
Hiremath J, Renu S, Tabynov K and Renukaradhya GJ. (2020). Pulmonary inflammatory response to influenza virus infection in pigs is regulated by DAP12 and macrophage M1 and M2 phenotypes. Cellular Immunology. 352: 104078. 1-7. Jun; 352:104078. doi: 10.1016/j.cellimm.2020.104078. Epub 2020 Feb 21. PMID: 32164997.
0008-8749 http://krishi.icar.gov.in/jspui/handle/123456789/46566 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Elsevier Publishers private limited
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