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Pulmonary inflammatory response to influenza virus infection in pigs is regulated by DAP12 and macrophage M1 and M2 phenotypes

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Title Pulmonary inflammatory response to influenza virus infection in pigs is regulated by DAP12 and macrophage M1 and M2 phenotypes
Not Available
 
Creator Hiremath J
Renu S
Tabynov K
Renukaradhya GJ
 
Subject Influenza A virus
DAP12
M1 and M2 macrophages
Pigs
 
Description Not Available
We delineated the expression of DAP12 (DNAX-Activating Protein) and its associated receptors, TREM-1, TREM-2 and MDL-1 in pig alveolar monocyte/macrophages (AMM) that have attained M1 or M2 phenotypes. Pig AMM stimulated in vitro with IFN-γ and IL-4 induced the expression of M1 (TNFα and iNOS) and M2 (ARG1 and no MMR) phenotypic markers, respectively. In influenza virus infected pigs at seven days post-infection, in addition to substantial modulations in the M1 and M2 markers expression, DAP12, TREM-1 and MDL-1 were downregulated in AMM. Thus, DAP12 signaling promoted the anti-inflammatory pathway in AMM of influenza virus infected pigs.
Not Available
 
Date 2021-04-22T03:56:22Z
2021-04-22T03:56:22Z
2020-02-21
 
Type Research Paper
 
Identifier Hiremath J, Renu S, Tabynov K and Renukaradhya GJ. (2020). Pulmonary inflammatory response to influenza virus infection in pigs is regulated by DAP12 and macrophage M1 and M2 phenotypes. Cellular Immunology. 352: 104078. 1-7. Jun; 352:104078. doi: 10.1016/j.cellimm.2020.104078. Epub 2020 Feb 21. PMID: 32164997.
0008-8749
http://krishi.icar.gov.in/jspui/handle/123456789/46566
 
Language English
 
Relation Not Available;
 
Publisher Elsevier Publishers private limited