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Neurobrucellosis: A neglected entity? An update from tertiary care Neurocentre of South East Asia

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Title Neurobrucellosis: A neglected entity? An update from tertiary care Neurocentre of South East Asia
Not Available
 
Creator Sayani M
Netravathi M
Veenakumari H
Bahubali
Shome R
Marimuthu P
Shayanki L
Raju R
Satishchandra P
Nagarathna C
 
Subject Brucellosis
Chronic meningitis
iELISA
Myelitis
Demyelination
GBS
Neurobrucellosis
 
Description Not Available
Neurobrucellosis is the most serious complication of brucellosis with neither a typical clinical manifestations nor
a specific cerebrospinal fluid (CSF) picture and mimics other neurological disorders leading to diagnostic dilemma. The prevalence of Neurobrucellosis ranges from 1.7 to 10% of brucellosis worldwide. This present study highlights the integrated diagnostic and clinical approaches in the diagnosis of neurobrucellosis. Cases with neurological abnormalities associated with abnormal CSF findings were included in the study. Serum and CSF samples were subjected to Rose Bengal Plate Test (RBPT), standard tube agglutination test (STAT), indirect Enzyme linked immunosorbent assay (iELISA) for IgM & IgG antibodies and polymerase chain reaction (PCR) to detect BCSP31 gene. Out of 473 cases, 278 (58.8%) were positive in serum and/or CSF by any
of the methods. Out of 278, Only IgM anti-brucella antibody was positive in 105 (22.19%) cases. 122 (25.79%)
cases were positive by any of the diagnostic methods in serum and not in CSF whereas 51(10.78%) cases were positive in serum and CSF and these 51 cases were considered as Neurobrucellosis among patients presenting with neurological illness. Chronic meningitis was the most common form of presentation. Multimodal differential diagnostic approaches are crucial for accurate diagnosis, effective treatment and to prevent morbidity and mortality associated with neurobrucellosis.
Not Available
 
Date 2021-04-22T04:26:30Z
2021-04-22T04:26:30Z
2020-01-16
 
Type Research Paper
 
Identifier Sayani M, Netravathi M, Veenakumari H, Bahubali, Shome R, Marimuthu P, Shayanki L, Raju R, Satishchandra P and Nagarathna C. (2020). Neurobrucellosis: A neglected entity? An update from tertiary care Neurocentre of South East Asia. Journal of the Neurological Sciences. 411:116683. https://doi.org/10.1016/j.jns.2020.116683
0022-510X
http://krishi.icar.gov.in/jspui/handle/123456789/46590
 
Language English
 
Relation Not Available;
 
Publisher Elsevier Publishers private limited