Pharmacokinetics of cefquinome after single intramuscular administration in dromedary camel (Camelus dromedarius)
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Title |
Pharmacokinetics of cefquinome after single intramuscular administration in dromedary camel (Camelus dromedarius)
Not Available |
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Creator |
Kant Lakshmi
Ranjan Amita Ranjan Rakesh Dumka VK Kaur Rajdeep |
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Subject |
Camel
Cefquinome Intramuscular Pharmacokinetics. |
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Description |
Not Available
The objective of this study was to investigate the pharmacokinetics of cefquinome in 5 healthy male dromedary camels following a single intramuscular (IM) administration at the dose rate of 1 mg/kg body weight in the caudal cervical epiaxial muscles. Blood samples were collected prior to drug administration and up to 48 h after drug administration. No clinical symptoms or signs suggestive of adverse drug reaction could be recorded in any animal. Plasma cefquinome concentration was estimated by high-performance liquid chromatography. The disposition kinetics of cefquinome best fitted to a 2 compartment open model. The peak plasma cefquinome concentration (Cmax cal) of 1.013 ± 0.038 μg/ml−1 was achieved at 5.257 ± 0.067 h (tmax cal). The absorption half-life (t½ka), elimination half-life (t½β), area under plasma drug concentration-time curve (AUC) and apparent volume of distribution (Vdarea) of cefquinome were 3.401 ± 0.042 h, 3.754 ± 0.072 h, 14.417 ± 0.621 μg/ml−1 h and 0.379 ± 0.016 l/kg−1, respectively. The results of the present study suggested that an intramuscular dosage regimen of 1 mg/kg body weight at 24 h interval would maintain the plasma drug levels required to be effective against the common bacterial pathogens in dromedary camel. Not Available |
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Date |
2021-04-30T08:25:11Z
2021-04-30T08:25:11Z 2019-04-01 |
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Type |
Article
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Identifier |
Not Available
0971-6777 http://krishi.icar.gov.in/jspui/handle/123456789/46926 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Camel Publishing House
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