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Pharmacokinetics of cefquinome after single intramuscular administration in dromedary camel (Camelus dromedarius)

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Title Pharmacokinetics of cefquinome after single intramuscular administration in dromedary camel (Camelus dromedarius)
Not Available
 
Creator Kant Lakshmi
Ranjan Amita
Ranjan Rakesh
Dumka VK
Kaur Rajdeep
 
Subject Camel
Cefquinome
Intramuscular
Pharmacokinetics.
 
Description Not Available
The objective of this study was to investigate the pharmacokinetics of cefquinome in 5 healthy male dromedary camels following a single intramuscular (IM) administration at the dose rate of 1 mg/kg body weight in the caudal cervical epiaxial muscles. Blood samples were collected prior to drug administration and up to 48 h after drug administration. No clinical symptoms or signs suggestive of adverse drug reaction could be recorded in any animal. Plasma cefquinome concentration was estimated by high-performance liquid chromatography. The disposition kinetics of cefquinome best fitted to a 2 compartment open model. The peak plasma cefquinome concentration (Cmax cal) of 1.013 ± 0.038 μg/ml−1 was achieved at 5.257 ± 0.067 h (tmax cal). The absorption half-life (t½ka), elimination half-life (t½β), area under plasma drug concentration-time curve (AUC) and apparent volume of distribution (Vdarea) of cefquinome were 3.401 ± 0.042 h, 3.754 ± 0.072 h, 14.417 ± 0.621 μg/ml−1 h and 0.379 ± 0.016 l/kg−1, respectively. The results of the present study suggested that an intramuscular dosage regimen of 1 mg/kg body weight at 24 h interval would maintain the plasma drug levels required to be effective against the common bacterial pathogens in dromedary camel.
Not Available
 
Date 2021-04-30T08:25:11Z
2021-04-30T08:25:11Z
2019-04-01
 
Type Article
 
Identifier Not Available
0971-6777
http://krishi.icar.gov.in/jspui/handle/123456789/46926
 
Language English
 
Relation Not Available;
 
Publisher Camel Publishing House