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Structural SCOP super family level classification using unsupervised machine learning

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Title Structural SCOP super family level classification using unsupervised machine learning
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Structural SCOP superfamily level classification using unsupervised machine learning , IEEE Transaction on Computational Biology and Bioinformatics, 9: 601-608
 
Creator Angadi UB
Venkatesulu M
 
Subject machine learning
 
Description Not Available
One of the major research directions in bioinformatics is that of assigning superfamily classification to a given set of proteins. The classification reflects the structural, evolutionary, and functional relatedness. These relationships are embodied in a hierarchical classification, such as the Structural Classification of Protein (SCOP), which is mostly manually curated. Such a classification is essential for the structural and functional analyses of proteins. Yet a large number of proteins remain unclassified. In this study, we have proposed an unsupervised machine learning approach to classify and assign a given set of proteins to SCOP superfamilies. In the method, we have constructed a database and similarity matrix using P-values obtained from an all-against-all BLAST run and trained the network with the ART2 unsupervised learning algorithm using the rows of the similarity matrix as input vectors, enabling the trained network to classify the proteins from 0.82 to 0.97 f-measure accuracy. The performance of ART2 has been compared with that of spectral clustering, Random forest, SVM, and HHpred. ART2 performs better than the others except HHpred. HHpred performs better than ART2 and the sum of errors is smaller than that of the other methods evaluated.
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Date 2021-08-04T03:24:03Z
2021-08-04T03:24:03Z
2011-08-04
 
Type Journal
 
Identifier Angadi UB, Venkatesulu M. Structural SCOP superfamily level classification using unsupervised machine learning. IEEE/ACM Trans Comput Biol Bioinform. 2012 Mar-Apr;9(2) 601-608. doi:10.1109/tcbb.2011.114. PMID: 21844638.j
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http://krishi.icar.gov.in/jspui/handle/123456789/52770
 
Language English
 
Relation Not Available;
 
Publisher Europe PMC