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Integrated effect of seasons and lactation stages on the plasma inflammatory cytokines, function and receptor expression of milk neutrophils in Sahiwal (Bos indicus) cows

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Title Integrated effect of seasons and lactation stages on the plasma inflammatory cytokines, function and receptor expression of milk neutrophils in Sahiwal (Bos indicus) cows
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Creator Not Available
 
Subject Mammary gland Phagocytosis Cortisol Interleukin Chemokine receptor Toll-like receptor
 
Description Not Available
Mastitis is a highly prevalent and one of the costliest diseases of dairy cows affecting the mammary gland. Milk
neutrophils present in the mammary gland serve as an integral part of the mammary immunity, and their
performance is influenced by different environmental conditions and lactation stages. To investigate the combined
effects of seasons and lactation stages on the mammary immunity, milk and blood samples were collected
from three groups of high producing indigenous Sahiwal cows. Function and receptor expression of milk neutrophils
together with cortisol and inflammatory interleukins concentration in blood were studied. The first
group of cows started their lactation in winter and completed their lactation in hot-humid season; the second
group started their lactation in hot-dry season and completed it in winter. The third group started their lactation
in hot-humid and completed by the hot-dry season. Plasma cortisol levels were very high during early lactation
in all seasons. An inverse relationship was observed between cortisol levels and glucocorticoid receptor. Elevated
phagocytic activity and plasma interleukin-2 levels were seen in winter and during mid lactation of all seasons. A
positive correlation was noticed between plasma IL-8, the percentage of milk neutrophils and expression of
chemokine receptors (CXCR1 and CXCR2). The highest expression of toll-like receptors (TLR2 and TLR4) and
chemokine receptors was in hot-humid season. Reduction in the phagocytic activity of neutrophils, pro-inflammatory
cytokines and elevated levels of cortisol in cows which started their lactation and attained peak
lactation during hot-humid season indicated more stress in them. Integrated influence of both seasons and
lactation stages on the activity of milk neutrophils along with plasma interleukins and cortisol levels may be used
to develop suitable managemental strategies to improve mammary health and increase milk production in indigenous
dairy breeds experiencing harsh environmental conditions.
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Date 2021-08-09T05:30:36Z
2021-08-09T05:30:36Z
2017-07-25
 
Type Research Paper
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/53701
 
Language English
 
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Publisher Not Available