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Integrated effect of seasons and lactation stages on the plasma inflammatory cytokines, function and receptor expression of milk neutrophils in Sahiwal (Bos Indicus) cows

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Title Integrated effect of seasons and lactation stages on the plasma inflammatory cytokines, function and receptor expression of milk neutrophils in Sahiwal (Bos Indicus) cows
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Creator Not Available
 
Subject Mammary gland, Phagocytosis, Cortisol, Interleukin, Chemokine receptor, Toll-like receptor
 
Description Not Available
Mastitis is a highly prevalent and one of the costliest diseases of dairy cows affecting the
mammary gland. Milk neutrophils present in the mammary gland serve as an integral part of the
mammary immunity, and their performance is influenced by different environmental conditions
and lactation stages. To investigate the combined effects of seasons and lactation stages on the
mammary immunity, milk and blood samples were collected from three groups of high
producing indigenous Sahiwal cows. Function and receptor expression of milk neutrophils
together with cortisol and inflammatory interleukins concentration in blood were studied. The
first group of cows started their lactation in winter and completed their lactation in hot-humid
season; the second group started their lactation in hot-dry season and completed it in winter. The
third group started their lactation in hot-humid and completed by the hot-dry season. Plasma
cortisol levels were very high during early lactation in all seasons. An inverse relationship was
observed between cortisol levels and glucocorticoid receptor. Elevated phagocytic activity and
plasma interleukin-2 levels were seen in winter and during mid lactation of all seasons. A
positive correlation was noticed between plasma IL-8, the percentage of milk neutrophils and
expression of chemokine receptors (CXCR1 and CXCR2). The highest expression of toll-like
receptors (TLR2 and TLR4) and chemokine receptors was in hot-humid season. Reduction in the
phagocytic activity of neutrophils, pro-inflammatory cytokines and elevated levels of cortisol in
cows which started their lactation and attained peak lactation during hot-humid season indicated
more stress in them. Integrated influence of both seasons and lactation stages on the activity of
milk neutrophils along with plasma interleukins and cortisol levels may be used to develop
suitable managemental strategies to improve mammary health and increase milk production in
indigenous dairy breeds experiencing harsh environmental conditions.
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Date 2021-08-26T08:17:19Z
2021-08-26T08:17:19Z
2017-07-25
 
Type Research Paper
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/60657
 
Language English
 
Relation Not Available;
 
Publisher Not Available