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Extraction of Cefquinome from Food by Magnetic Molecularly Imprinted Polymer.

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Title Extraction of Cefquinome from Food by Magnetic Molecularly Imprinted Polymer.
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Creator Aggarwal, S.; Rajput, Y.S.; Sharma, R. and Pandey, A.K.
 
Subject Cefquinome; Imprinted polymer; Magnetite; Selectivity; Extraction; FTIR; Polymerization
 
Description Not Available
Cefquinome is a fourth generation cephalosporin with broad spectrum antimicrobial activity. It is
commonly used against respiratory tract diseases, acute mastitis, calf septicemia and foot rot in livestock. Clean-up
step in sample preparation is invariably required for avoiding interferences in assay from other components. It is
envisaged to prepare molecular imprinted based polymer with desired selectivity for cefquinome. Method: Imprinted
polymer was synthesized over the surface of magnetite using methacrylate (monomer) acid and
ethyleneglycoldimethacrylate (crosslinker) in the presence of cefquinome (imprint molecule). Magnetite was
prepared by co-precipitation of 1.98 g FeCl2.4H2O and 5.41 g FeCl3.6H2O. Magnetic non-imprinted polymer was
prepared similarly in absence of cefquinome. Selectivity in different solvent was calculated from partition coefficient
values in imprinted and non-imprinted polymers. Result: Selectivity of imprinted polymer over non-imprinted polymer
was dependent on nature of solvent and pH. Binding of cefquinome was highly selective in acetonitrile. Imprinted
polymer lacks selectivity in methanol and 1M NaCl. Ionic interaction between quinolinium ion in cefquinome and
carboxylate anion in polymer appears to be major force for recognition of cefquinome by imprinted polymer.
Prepared polymer extracted cefquinome from milk, honey, egg and water and extraction efficiency was in the range
of 74-93.7%. Conclusion: Selectivity of magnetic imprinted polymer must be determined in different solvents and this
will enable selecting binding and elution conditions during extraction of imprint molecule.
Not Available
 
Date 2021-08-26T08:24:53Z
2021-08-26T08:24:53Z
2016-12-05
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/60709
 
Language English
 
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Publisher Not Available