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Fat accumulation in differentiated brown adipocytes is linked with expression of Hox genes

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Title Fat accumulation in differentiated brown adipocytes is linked with expression of Hox genes
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Creator Singh, S.; Rajput, Y.S.; Barui, A.K.; Sharma, R. and Datta, T.K.
 
Subject Singh, S.; Rajput, Y.S.; Barui, A.K.; Sharma, R. and Datta, T.K.
 
Description Not Available
Homeobox (Hox) genes are involved in body plan of embryo along the anterioreposterior axis. Presence
of several Hox genes in white adipose tissue (WAT) and brown adipose tissue (BAT) is indicative of
involvement of Hox genes in adipogenesis. We propose that differentiation inducing agents viz. isobutyl methyl-xanthine (IBMX), indomethacin, dexamethasone (DEX), triiodothyronine (T3) and insulin may
regulate differentiation in brown adipose tissue through Hox genes. In vitro culture of brown fat stro malvascular fraction (SVF) in presence or absence of differentiation inducing agents was used for
establishing relationship between fat accumulation in differentiated adipocytes and expression of Hox
genes. Relative expression of Pref1, UCP1 and Hox genes was determined in different stages of adipo genesis. Presence or absence of IBMX, indomethacin and DEX during differentiation of proliferated pre adipocytes resulted in marked differences in expression of Hox genes and lipid accumulation. In presence
of these inducing agents, lipid accumulation as well as expression of HoxA1, HoxA5, HoxC4 & HoxC8
markedly enhanced. Irrespective of presence or absence of T3, insulin down regulates HoxA10. T3 results
in over expression of HoxA5, HoxC4 and HoxC8 genes, whereas insulin up regulates expression of only
HoxC8. Findings suggest that accumulation of fat in differentiated adipocytes is linked with expression of
Hox genes.
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Date 2021-08-26T08:31:56Z
2021-08-26T08:31:56Z
2016-01-01
 
Type Research Paper
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/60756
 
Language English
 
Relation Not Available;
 
Publisher Not Available