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Process Optimization for the production of nanoencapsulated curcumin and analysis for physicochemical characteristics and antioxidant mechanism.

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Title Process Optimization for the production of nanoencapsulated curcumin and analysis for physicochemical characteristics and antioxidant mechanism.
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Creator Sari, T.P.; Mann, B.; Sharma, R.; Kumar, R.; Vikrant and Minaxi
 
Subject Curcumin Nanoencapsulation Bioavailability Nanoemulsion Simulated gastrointestinal digestion
 
Description Not Available
Curcumin is the most active and least stable bioactive component of turmeric (Curcuma longa) plant. In
the present study, an attempt has been made to overcome the instability during processing and
bioavailability problems of curcumin by nanoencapsulation technology and the effect was evaluated by
simulated digestion study. Curcumin was encapsulated in medium chain triglyceride oil droplets of
nanoemulsion prepared by ultrasonification using whey protein concentrate-70 and Tween-80 as
emulsifiers with an encapsulation efficiency of 90.56 ± 0.47%. The prepared nanoemulsion has particles of
average diameter 141.6 ± 15.4 nm and zeta potential of 6.9 ± 0.2 mV. In vitro release kinetics of cur cumin from nanoemulsion by simulated gastrointestinal studies showed that the curcumin nanoemulsion
was relatively resistant to pepsin digestion but pancreatin causes release of curcumin from nanoemulsion.
The slow release of curcumin from the nanoemulsion was supposed to increase bioavailability. The total
antioxidant activity of curcumin nanoemulsion was reduced from 3.53 ± 0.11 mM Trolox/mg of curcumin
to 3.33 ± 0.02 mM Trolox/mg of curcumin after encapsulation. The prepared nanoemulsion was stable to
pasteurization, different ionic strengths (0.1e1 M) and pH ranging from 3.0 to 7.0. The study has
important implication in the formation and design of encapsulated bioactive systems.
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Date 2021-08-26T08:28:45Z
2021-08-26T08:28:45Z
2014-07-22
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/60732
 
Language English
 
Relation Not Available;
 
Publisher Not Available