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GC-MS/MS Based Phytochemical Screening Revealed the Therapeutic Potential of Calligonum polygonoides L. Flower Bud Against Chronic Diseases

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Title GC-MS/MS Based Phytochemical Screening Revealed the Therapeutic Potential of Calligonum polygonoides L. Flower Bud Against Chronic Diseases
 
Creator Mukesh Kumar Berwal
 
Subject Phog,GC-MS/MS,Phenolic compounds,antioxidant. chronic disearse
 
Description Not Available
Background: Calligonum polygonoidesis an endemic plant species, belongs to Polygonaceae family, native to the ?Thar Desert? of India. It is highly tolerant to multiple stresses with dominant biomass and phytochemical producer under extreme niche. It has significant ethnopharmacological applications, but not yet scientifically validated. Materials and Methods: The methanolic extract of C. polygonoides flower bud was subjected to Gas Chromatography Mass spectroscopy (GC-MS/MS) analysis and antioxidant potential assay was done on different radical scavenging scales. The phytochemicals were identified based on retention time and matching their mass spectra to spectra in NIST 14 library. Results: The results revealed presence of fatty acids, phenolics, terpenoides, flavanoids, alkaloids, tannins, steroids, ketones, esters and amino acid derivatives, which comprises of 93 compounds. Most of the detected compounds have been proved to possess important bio-activities like anti-microbial, anti-inflammatory, anticancer, anti-diabetic, hepatoprotective, cardiovascular, antioxidant, antimutagenic etc. Interestingly, some compounds like Furan-2,5-dimethyl, DDMP, Dehydromevalonic lactone, Deoxyspergualin, 2-Methoxy-4-vinylphenol, Benzeneethanol-4-Hydroxy-, Quinic acid, Lauric acid, Linolenic acid and Squalene were detected which have proved pharmaceuticals applications against major diseases like cancer, diabetics, cardiovascular and some other chronic diseases. Furthermore, the methanolic extract also attributed very high level of antioxidant potential on Cupric Reducing Antioxidant Capacity (CUPRAC), Ferric Reducing Antioxidant Power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and Phosphomolybdenum (PM) assay scales. Conclusion: The identified phytochemicals with ample pharmaceutical application explore the worthiness of this endemic plant species. Along with pharmaceutical, it has an immense scope in nutraceutical and functional food industry. These medicinal importance advised for its conservation and artificial regeneration, in-order to sustain the agro-ecological balance of Thar Desert of India.
 
Date 2021-04-24T06:33:40Z
2021-04-24T06:33:40Z
2021-1-1
 
Type Research Paper
 
Identifier MK Berwal, Haldhar SM, Chet Ram, Gora JS, SIngh D and Samadia DK (2021). GC-MS/MS Based Phytochemical Screening Revealed the Therapeutic Potential of Calligonum polygonoides L. Flower Bud Against Chronic Diseases. Pharmacognosy Magazine (Accepted).
Not Available
0973-1296
http://krishi.icar.gov.in/jspui/handle/123456789/46677
 
Language English
 
Publisher Not Available