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The viridin biosynthesis gene cluster of Trichoderma virens and its conservancy in the bat white-nose fungus Pseudogymnoascus destructans

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Title The viridin biosynthesis gene cluster of Trichoderma virens and its conservancy in the bat white-nose fungus Pseudogymnoascus destructans
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Creator Bansal R., Sherkhane P.D., Oulkar D., Khan Z., Banerjee Kaushik, Mukherjee P.K.
 
Subject Viridin biosynthesis
Metabolites of Trichoderma virens
LC-MS
 
Description Not Available
Viridin group of furano‐steroidal antibiotics are known to function as anti‐fungal and anti‐cancer agents, in addition to their roles as radio‐ and chemo‐sensitizers. Discovered in 1945 as a metabolite of Trichoderma virens , viridins continue to receive significant attention of several synthetic chemists and clinicians as a very strong PI3 kinase inhibitor. However, till date, researchers have not been able to discover a single gene that is involved in viridin biosynthesis. In this study, we present the complete gene cluster for the biosynthesis of viridin in T. virens , and provide genetic evidence of its involvement in viridin formation. Also, we show that the same cluster is present in a distantly related fungus Pseudogymnoascus destructans that causes bat white‐nose disease, which is leading to the devastation of the bat population in North America. Our findings, thus, pave not only the way for further research on the elucidation of the complete biosynthesis pathway and possible tuning of viridin production in the plant beneficial fungus Trichoderma virens , but also are expected to trigger investigations on the role of this gene cluster in pathogenicity of the devastating bat pathogen.
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Date 2020-07-31T06:28:30Z
2020-07-31T06:28:30Z
2018-01-30
 
Type Journal
 
Identifier Bansal R., Sherkhane P.D., Oulkar D., Khan Z., Banerjee Kaushik, Mukherjee P.K. (2018). The viridin biosynthesis gene cluster of Trichoderma virens and its conservancy in the bat white-nose fungus Pseudogymnoascus destructans. ChemistrySelect 3, 1289-1293
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.201703035
http://krishi.icar.gov.in/jspui/handle/123456789/38654
 
Language English
 
Relation Not Available;
 
Publisher Chemistry Europe