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Genomics-driven discovery of the gliovirin biosynthesis gene cluster in the plant beneficial fungus Trichoderma virens

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Title Genomics-driven discovery of the gliovirin biosynthesis gene cluster in the plant beneficial fungus Trichoderma virens
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Creator Sherkhane P.D., Bansal R., Banerjee Kaushik, Chatterjee S., Oulkar D., Jain P., Rosenfelder L., Elgavish S., Horwitz B.A., Mukherjee P.K.
 
Subject Gliovirin
Trichoderma metabolites
Metabolite identification by LC-MS
High resolution accurate mass analysis
 
Description Not Available
Gliovirin is a strong anti‐oomycete and a candidate anticancer compound. It is produced by “P” strains of the plant disease biocontrol fungus Trichoderma virens and is involved in biological control of certain plant pathogens. Even though the compound is known for more than three decades, neither the genes involved nor the biosynthetic pathway are known. We have sequenced the whole genome of a gliovirin producing strain of T. virens and discovered a novel gene cluster comprising of 22 genes. Disruption of the non‐ribosomal peptide synthetase eliminated biosynthesis of gliovirin. The gene cluster is very similar to a hitherto un‐described gene cluster of Aspergillus udagawae , a human pathogen. Our findings open‐up the possibility of strain improvement of T. virens for improved biocontrol of plant diseases through enhanced production of gliovirin. Research also can now be initiated on the role of this gene cluster in pathogenicity of the human pathogen A. udagawae.
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Date 2020-07-31T06:34:30Z
2020-07-31T06:34:30Z
2017-04-19
 
Type Journal
 
Identifier Sherkhane P.D., Bansal R., Banerjee Kaushik, Chatterjee S., Oulkar D., Jain P., Rosenfelder L., Elgavish S., Horwitz B.A., Mukherjee P.K. (2017). Genomics-driven discovery of the gliovirin biosynthesis gene cluster in the plant beneficial fungus Trichoderma virens. ChemistrySelect 2, 3347-3352
https://doi.org/10.1002/slct.201700262
http://krishi.icar.gov.in/jspui/handle/123456789/38661
 
Language English
 
Relation Not Available;
 
Publisher Chemistry Europe