Genomics-driven discovery of the gliovirin biosynthesis gene cluster in the plant beneficial fungus Trichoderma virens
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Title |
Genomics-driven discovery of the gliovirin biosynthesis gene cluster in the plant beneficial fungus Trichoderma virens
Not Available |
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Creator |
Sherkhane P.D., Bansal R., Banerjee Kaushik, Chatterjee S., Oulkar D., Jain P., Rosenfelder L., Elgavish S., Horwitz B.A., Mukherjee P.K.
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Subject |
Gliovirin
Trichoderma metabolites Metabolite identification by LC-MS High resolution accurate mass analysis |
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Description |
Not Available
Gliovirin is a strong anti‐oomycete and a candidate anticancer compound. It is produced by “P” strains of the plant disease biocontrol fungus Trichoderma virens and is involved in biological control of certain plant pathogens. Even though the compound is known for more than three decades, neither the genes involved nor the biosynthetic pathway are known. We have sequenced the whole genome of a gliovirin producing strain of T. virens and discovered a novel gene cluster comprising of 22 genes. Disruption of the non‐ribosomal peptide synthetase eliminated biosynthesis of gliovirin. The gene cluster is very similar to a hitherto un‐described gene cluster of Aspergillus udagawae , a human pathogen. Our findings open‐up the possibility of strain improvement of T. virens for improved biocontrol of plant diseases through enhanced production of gliovirin. Research also can now be initiated on the role of this gene cluster in pathogenicity of the human pathogen A. udagawae. Not Available |
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Date |
2020-07-31T06:34:30Z
2020-07-31T06:34:30Z 2017-04-19 |
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Type |
Journal
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Identifier |
Sherkhane P.D., Bansal R., Banerjee Kaushik, Chatterjee S., Oulkar D., Jain P., Rosenfelder L., Elgavish S., Horwitz B.A., Mukherjee P.K. (2017). Genomics-driven discovery of the gliovirin biosynthesis gene cluster in the plant beneficial fungus Trichoderma virens. ChemistrySelect 2, 3347-3352
https://doi.org/10.1002/slct.201700262 http://krishi.icar.gov.in/jspui/handle/123456789/38661 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Chemistry Europe
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