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Effect of Benzalkonium chloride (BKC) on the blood cells and immune system of Calrius batrachus

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Title Effect of Benzalkonium chloride (BKC) on the blood cells and immune system of Calrius batrachus
Not Available
 
Creator Madhu. V.R
Pani Prasad. K
Hina Alim
 
Subject Clarias batrachus
BKC
Immunostimulation
Blood cells
 
Description Not Available
The increase in aquaculture production is coupled with an increase in disease outbreaks and to control
diseases especially caused by bacteria, antibiotics are being used indiscriminately. The resultant setbacks
have focused the attention on the use of immunostimulants in aquaculture practice to withstand the
pathogens. To avoid the use of antibiotics, attempts were made to study the immunomodulatory effect of
Benzalkonium Chloride (BKC) in Clarias batrachus. BKC is a quaternary ammonium compound that can
modify non-specific and specific responses and can be used as an immunomodulator in fishes. To determine
the immunomodulatory effect and optimum doses to be applied as injection, bath and feed, the catfish
Clarias batrachus was used as an animal model. BKC was applied in three forms, i.e. injection at the rate of
5, 50 and 500 g/kg of the fish weight, bath at 2 and 3 ppm levels for 1 hour and incorporated in feed @ of 1,
5 and 50 mg per kilogram dry weight of feed. White blood cells counts, differential counts, phagocytosis,
agglutination assay, NBT assay and serum bacterial activity of the fish was performed for assessing the
changes in specific and non-specific responses to BKC. The BKC treated fishes showed increased nonspecific and specific responses in comparison to untreated control. The fishes treated with immunostimulant and later challenged with a virulent strain of Aeromonas hydrophila, showed delayed and lower mortality than the untreated controls. The present study suggests that BKC can be used as an immunostimulant and can be administered in different forms, like injection, 3 ppm as bath and 50mg/kg dry weight of BKC in feed.
Not Available
 
Date 2017-02-25T11:30:47Z
2017-02-25T11:30:47Z
2014-01-01
 
Type Research Paper
 
Identifier International Journal of Fisheries and Aquaculture Studies, 1(4): 32-40,2014
2347-5129
http://krishi.icar.gov.in/jspui/handle/123456789/2770
 
Language English
 
Relation Not Available;
 
Publisher CIFE, Mumbai