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Investigation of cadmium-induced genotoxicity and oxidative stress response in Indian major carp, Labeo rohita

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Title Investigation of cadmium-induced genotoxicity and oxidative stress response in Indian major carp, Labeo rohita
Not Available
 
Creator Anurag Dabas
N. S. Nagpure
R. M. Mishra
Basdeo Kushwaha
Ravindra Kumar
Pavan Kumar
 
Subject cadmium, genotoxicity, Labeo rohita , oxidative stress, antioxidant enzymes
 
Description Not Available
We investigated genotoxicity and oxidative stress in the gills of Labeo rohita exposed
to 33.6, 67.1, and 100.6 mg L–1 of cadmium chloride at 96 h. Genotoxicity was
assessed using single cell gel electrophoresis whereas oxidative stress was monitored
through lipid peroxidation induction and antioxidant response parameters, namely
reduced glutathione (GSH), glutathione peroxidase, glutathione-S-transferase, superoxide
dismutase, and catalase (CAT) activities. Significant (p < .05) effect of both
concentration and time of exposure was observed on the extent of DNA damage
in treated fish. Similarly, malondialdehyde content, level of GSH, and activities of
antioxidant enzymes were significantly elevated in treated groups, except CAT. The
increased DNA damage and lipid peroxidation (LPO) content along with fluctuation
in antioxidant defense system in fish indicated the interaction of cadmium (Cd)
with DNA repair processes and production of reactive oxygen species. Thus, Cd is
liable for induction of LPO, alteration of antioxidant defenses, and DNA damage
in gills of L. rohita
Not Available
 
Date 2017-03-30T07:27:05Z
2017-03-30T07:27:05Z
2012-07-09
 
Type Research Paper
 
Identifier Anurag Dabas , N. S. Nagpure , R. M. Mishra , Basdeo Kushwaha , Ravindra Kumar & Pavan Kumar (2014) Investigation of Cadmium-Induced Genotoxicity and Oxidative Stress Response in Indian Major Carp, Labeo rohita
1080-7039
http://krishi.icar.gov.in/jspui/handle/123456789/3481
 
Language English
 
Relation Not Available;
 
Publisher Human and Ecological Risk Assessment