Gastroprotective effect of Sardine oil(Sardinella longiceps) against HCL/ethanol induced ulceration in Wistar rats
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Title |
Gastroprotective effect of Sardine oil(Sardinella longiceps) against HCL/ethanol induced ulceration in Wistar rats
Not Available |
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Creator |
Vishnu, K.V.
Ajeeshkumar, K.K. Remyakumari, K.R. Ganesan, B. Chatterjee, N.S Lekshmi, R.G.K. Shyni, K. Suseela Mathew |
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Subject |
Sardine oil
anti-ulcer n-3 PUFA gastic mucosa |
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Description |
Not Available
Sardine oil is rich in n-3 polyunsaturated fatty acids (PUFAs) like EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). The oil showed a significant proportion of n-3 polyunsaturated fatty acids (PUFAs), the percentages of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) being 16 and 14% respectively. Gastroprotective activities of sardine oil (Sardinella longiceps) were examined in ulcer induced rats. Sardine oil has significant anti-secretory activity as evidenced by decreased gastric fluid volume, total acidity, and increase in the pH of the gastric fluid in ethanol/HCl induced rats. Our studies also revealed that pretreatment with sardine oil significantly reduced the number of ulcer, ulcer score and ulcer index in ethanol/HCl treated rats. The anti-ulcer activity of sardine oil is further supported by histopathological study, which showed protection of the mucosal layer from ulceration. Furthermore, this oil showed significant reversal of ethanol-diminished activity in antioxidant enzymes, such as SOD, CAT, and GSH. The overall findings conclude that oil of Sardinella longiceps has a significant proportion of n-3 polyunsaturated fatty acids and potent anti-ulcer effects. Hence, sardine oil may be a suitable natural source for the prevention and treatment of gastric lesions. Not Available |
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Date |
2018-11-29T16:51:32Z
2018-11-29T16:51:32Z 2017-02-20 |
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Type |
Research Paper
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Identifier |
Vishnu, K.V., Ajeeshkumar, K.K., Remyakumari, K.R., Ganesan, B, Chatterjee, N.S., Lekshmi, R.G.K., Shyni, K. and Suseela Mathew (2017) - Gastroprotective effect of sardine oil (Sardinella longiceps) against HCl/ethanol induced ulceration in Wistar rats, Intl J. Fish. Aquatic Stud. 5(2):118-124.
2347-5129(Online) 2394-0506 (Print) http://krishi.icar.gov.in/jspui/handle/123456789/14232 |
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Language |
English
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Relation |
Not Available;
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Publisher |
IIJFAS
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