Record Details

Gastroprotective effect of Sardine oil(Sardinella longiceps) against HCL/ethanol induced ulceration in Wistar rats

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title Gastroprotective effect of Sardine oil(Sardinella longiceps) against HCL/ethanol induced ulceration in Wistar rats
Not Available
 
Creator Vishnu, K.V.
Ajeeshkumar, K.K.
Remyakumari, K.R.
Ganesan, B.
Chatterjee, N.S
Lekshmi, R.G.K.
Shyni, K.
Suseela Mathew
 
Subject Sardine oil
anti-ulcer
n-3 PUFA
gastic mucosa
 
Description Not Available
Sardine oil is rich in n-3 polyunsaturated fatty acids (PUFAs) like EPA (eicosapentaenoic acid) and DHA
(docosahexaenoic acid). The oil showed a significant proportion of n-3 polyunsaturated fatty acids
(PUFAs), the percentages of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) being 16
and 14% respectively. Gastroprotective activities of sardine oil (Sardinella longiceps) were examined in
ulcer induced rats. Sardine oil has significant anti-secretory activity as evidenced by decreased gastric
fluid volume, total acidity, and increase in the pH of the gastric fluid in ethanol/HCl induced rats. Our
studies also revealed that pretreatment with sardine oil significantly reduced the number of ulcer, ulcer
score and ulcer index in ethanol/HCl treated rats. The anti-ulcer activity of sardine oil is further
supported by histopathological study, which showed protection of the mucosal layer from ulceration.
Furthermore, this oil showed significant reversal of ethanol-diminished activity in antioxidant enzymes,
such as SOD, CAT, and GSH. The overall findings conclude that oil of Sardinella longiceps has a
significant proportion of n-3 polyunsaturated fatty acids and potent anti-ulcer effects. Hence, sardine oil
may be a suitable natural source for the prevention and treatment of gastric lesions.
Not Available
 
Date 2018-11-29T16:51:32Z
2018-11-29T16:51:32Z
2017-02-20
 
Type Research Paper
 
Identifier Vishnu, K.V., Ajeeshkumar, K.K., Remyakumari, K.R., Ganesan, B, Chatterjee, N.S., Lekshmi, R.G.K., Shyni, K. and Suseela Mathew (2017) - Gastroprotective effect of sardine oil (Sardinella longiceps) against HCl/ethanol induced ulceration in Wistar rats, Intl J. Fish. Aquatic Stud. 5(2):118-124.
2347-5129(Online) 2394-0506 (Print)
http://krishi.icar.gov.in/jspui/handle/123456789/14232
 
Language English
 
Relation Not Available;
 
Publisher IIJFAS