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Microencapsulation of β-Carotene with Vanillic Acid Grafted Chitosan Improves Stability and Glutathione Content in Rats

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Title Microencapsulation of β-Carotene with Vanillic Acid Grafted Chitosan Improves Stability and Glutathione Content in Rats
Not Available
 
Creator Asha, K.K.
Ajeesh Kumar, K. K.
Chatterjee, N. S.
Anandan, R.
Suseela Mathew
 
Subject Antioxidant property
microencapsulation
vanillic acid grafted chitosan
Vitamin A deficiency
β-carotene
 
Description Not Available
Introduction: The most common cause of Vitamin A deficiency is insufficient intake of Vitamin A and one of the ways to deal with this challenge is using beta-carotene for food fortification. In our study, we addressed the concern of instability in beta-carotene molecules by microencapsulation with vanillic acid grafted chitosan. Methods and Materials: Beta-Carotene was microencapsulated using vanillic acid-grafted chitosan as wall material. Microencapsulation efficiency and morphology were determined. Size and shape of encapsulated beta-carotene particles were determined by a Zetasizer and scanning electron microscope, respectively. Beta-Carotene concentration was determined by HPLC while TBARS and glutathione in serum were assayed by spectrophotometric methods.
Results: The particles formed were confirmed to be in the microrange and also were smooth walled spherical units devoid of cracks and pores. Structures of free and encapsulated beta-carotene were compared by Fourier transform-infrared spectroscopy. Encapsulated beta-carotene particles showed better stability to degradation by light and exposure to oxidation. Analysis of beta-carotene in liver, plasma, and urine following 1 week of feeding either free beta-carotene or microencapsulated beta-carotene (mBC) in two groups of rats showed significantly (P less than 0.001) higher content in liver and plasma of mBC-fed rats. While glutathione content was raised significantly in mBC-fed rats, the level of thiobarbituric acid reacting substances was found
unchanged between the groups. Conclusions: This is the first instance of a report on microencapsulation of beta-carotene with vannilic acid-grafted chitosan. Structural characterization showed that particles formed were of micro-size range with smooth walls devoid of cracks and pores.
Not Available
 
Date 2019-06-15T17:04:44Z
2019-06-15T17:04:44Z
2018
 
Type Research Paper
 
Identifier Asha, K.K., Ajeeshkumar, K.K., Chatterjee, N.S., Anandan, R. and Suseela Mathew (2018) Microencapsulation of β-Carotene with Vanillic Acid Grafted Chitosan Improves Stability and Glutathione Content in Rats. Clinical Journal of Nutrition and Dietetics. 1(1): 1-7.
2639-8761
http://krishi.icar.gov.in/jspui/handle/123456789/20345
 
Language English
 
Relation Not Available;
 
Publisher Asclepius