Microencapsulation of β-Carotene with Vanillic Acid Grafted Chitosan Improves Stability and Glutathione Content in Rats
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Title |
Microencapsulation of β-Carotene with Vanillic Acid Grafted Chitosan Improves Stability and Glutathione Content in Rats
Not Available |
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Creator |
Asha, K.K.
Ajeesh Kumar, K. K. Chatterjee, N. S. Anandan, R. Suseela Mathew |
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Subject |
Antioxidant property
microencapsulation vanillic acid grafted chitosan Vitamin A deficiency β-carotene |
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Description |
Not Available
Introduction: The most common cause of Vitamin A deficiency is insufficient intake of Vitamin A and one of the ways to deal with this challenge is using beta-carotene for food fortification. In our study, we addressed the concern of instability in beta-carotene molecules by microencapsulation with vanillic acid grafted chitosan. Methods and Materials: Beta-Carotene was microencapsulated using vanillic acid-grafted chitosan as wall material. Microencapsulation efficiency and morphology were determined. Size and shape of encapsulated beta-carotene particles were determined by a Zetasizer and scanning electron microscope, respectively. Beta-Carotene concentration was determined by HPLC while TBARS and glutathione in serum were assayed by spectrophotometric methods. Results: The particles formed were confirmed to be in the microrange and also were smooth walled spherical units devoid of cracks and pores. Structures of free and encapsulated beta-carotene were compared by Fourier transform-infrared spectroscopy. Encapsulated beta-carotene particles showed better stability to degradation by light and exposure to oxidation. Analysis of beta-carotene in liver, plasma, and urine following 1 week of feeding either free beta-carotene or microencapsulated beta-carotene (mBC) in two groups of rats showed significantly (P less than 0.001) higher content in liver and plasma of mBC-fed rats. While glutathione content was raised significantly in mBC-fed rats, the level of thiobarbituric acid reacting substances was found unchanged between the groups. Conclusions: This is the first instance of a report on microencapsulation of beta-carotene with vannilic acid-grafted chitosan. Structural characterization showed that particles formed were of micro-size range with smooth walls devoid of cracks and pores. Not Available |
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Date |
2019-06-15T17:04:44Z
2019-06-15T17:04:44Z 2018 |
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Type |
Research Paper
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Identifier |
Asha, K.K., Ajeeshkumar, K.K., Chatterjee, N.S., Anandan, R. and Suseela Mathew (2018) Microencapsulation of β-Carotene with Vanillic Acid Grafted Chitosan Improves Stability and Glutathione Content in Rats. Clinical Journal of Nutrition and Dietetics. 1(1): 1-7.
2639-8761 http://krishi.icar.gov.in/jspui/handle/123456789/20345 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Asclepius
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