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Biochemical Studies on the Cardioprotective Effect of Glutamine on Tissue Antioxidant Defense System in Isoprenaline-Induced Myocardial Infarction in Rats

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Title Biochemical Studies on the Cardioprotective Effect of Glutamine on Tissue Antioxidant Defense System in Isoprenaline-Induced Myocardial Infarction in Rats
Not Available
 
Creator Kumar, S. H. S.
Anandan, R.
 
Subject Glutamine
isoprenaline
myocardial infraction
antioxidant status
diagnostic marker enzymes
 
Description Not Available
Oxidative stress is one of the mechanisms with a central role involved in the pathogenesis of myocardial infarction. The protective effect of glutamine on myocardial antioxidant defense system was investigated during isoprenaline-induced myocardial infarction, an animal model of myocardial infarction of human beings. Levels of diagnostic marker enzymes in plasma, reduced glutathione (GSH) and lipid peroxides and the activities of glutathione peroxidase, glutathione-S-transferase, catalase and superoxide dismutase in heart tissue were determined. Injection of isoprenaline caused significant increases in the levels of diagnostic marker enzymes in plasma and lipid peroxidation in heart tissue. A parallel decline in the levels of ATP (Adenosine triphosphate) and GSH and the activities of glutathione-dependent antioxidant enzymes and antiperoxidative enzymes in heart tissue was also observed. Prior oral administration of glutamine significantly prevented isoprenaline-induced adverse effects and maintained myocardial antioxidant status at near normal status. The cardioprotective effect of glutamine is probably related to a strengthening of the myocardial membrane by its membrane stabilizing action, or to a counteraction of free radicals by its antioxidant property, or to its ability to maintain near to normal status the activities of free radical scavenging enzymes and the level of GSH, which protect myocardial membrane against oxidative damage by decreasing lipid peroxidation.
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Date 2021-07-29T09:16:29Z
2021-07-29T09:16:29Z
2007
 
Type Research Paper
 
Identifier Kumar, S. H. S. and Anandan, R. (2007) Biochemical studies on the cardioprotective effect of glutamine on tissue antioxidant defence system in isoprenaline-induced myocardial infraction in rats. J. Clin. Biochem. Nutr. 40: 49-55.
0912-0009
http://krishi.icar.gov.in/jspui/handle/123456789/51073
 
Language English
 
Relation Not Available;
 
Publisher Institute of Applied Biochemistry (Japan)