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Fabrication and characterization of chitosan conjugated eurycomanone nanoparticles: In vivo evaluation of the biodistribution and toxicity in fish

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Title Fabrication and characterization of chitosan conjugated eurycomanone nanoparticles: In vivo evaluation of the biodistribution and toxicity in fish
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Creator Bhat, I. A., Nazir, M. I., Ahmad, I., Gireesh-Babu, P., Chanu, T. I., Goswami, M., Sundaray, J.K., Sharma R*
 
Subject Nanoparticles SEM FTIR Rhodamine-6G Testes Catfish
 
Description Not Available
Chitosan nanoparticles (CNPs) have been proven considerable delivery agents due to their remarkable physicochemical
properties. Present study reports the fabrication of CNPs by ionic gelation process and their characterization
by different approaches. The constructed nanoparticles were successfully conjugated with eurycomanone with significant
entrapment efficiency. Particle size of chitosan and chitosan conjugated eurycomanone nanoparticles were
126.2 nmand 130 nmrespectively. Scanning electron microscopy showed that the particleswere spherical in shape
and well dispersed. Cross-linking between CNPs and eurycomanone (CENPs) were confirmed by Fourier-transform
infrared (FTIR) spectroscopy. Fluorescent nanoparticles were prepared by using Rhodamine-6G dye, characterised
by SEM and confirmed for conjugation by FTIR. Biodistribution of CENPs showed the presence of fluorescent nanoparticles
in liver, kidney, testes and brain of C. magur. The toxicity of CENPs was evaluated by comparing the histological
sections of catfish testes collected fromtreated and control group.No signs of toxicitywere seen in testes after
the delivery of CENPs. Molecular docking study revealed high spontaneous binding ability of chitosan with
eurycomanone and aromatase enzyme. The study reports that CNPs can act as a stabilizing agent for eurycomanone
formulation and could be a promising approach to increase the reproductive performance of the fishes.
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Date 2022-06-15T10:50:20Z
2022-06-15T10:50:20Z
2018-02-11
 
Type Research Paper
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/72560
 
Language English
 
Relation Not Available;
 
Publisher ELSEVIER