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Evaluation of safety and withdrawal period of orally administered Oxytetracycline (OTC) in advance fingerlings of Cirrhinus mrigala (Hamilton, 1822)

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Title Evaluation of safety and withdrawal period of orally administered Oxytetracycline (OTC) in advance fingerlings of Cirrhinus mrigala (Hamilton, 1822)
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Creator H.G. Solanki, S. Avunje, R. Ananda Raja, B.J. Trangadia, Anand Verma, J.G. Vanza, M.R. Patel, R.B. Vala, R.V. Borichangar, P.K. Patil
 
Subject Aquaculture, Mrigal, Medicated feed, Antibiotic residue, Food safety
 
Description Not Available
The present study reports the safety and withdrawal period of orally administered oxytetracycline in advance fingerlings of Cirrhinus mrigala. For evaluation of safety, the drug was administered as feed-top dressing @ 80, 240, 400 and 800 mg kg−1 fish biomass per day consecutively for 30 days. Samples of liver, kidney, gills were collected at ten days intervals for histopathological examination. For determination of withdrawal period, fish were administered orally at the therapeutic dose of 80 mg kg−1 day−1 consecutively for ten days, and an edible portion (muscle-skin) was collected for estimation of residue levels at 48 h intervals after the termination of medication. The animal behaviour was observed daily, and growth was measured once in 10 days. The drug was well tolerated up to 240 mg kg−1 while fish administered with higher doses (400 mg and 800 mg kg−1 day−1) showed growth retardation. Histopathological examination revealed mild to moderate changes in the gills, liver and kidney in the group receiving 400 and 800 mg kg-1 concentration of OTC. Residue analysis using LC-MS/MS showed the highest concentration of the drug in the liver (13.53 mg kg−1) followed by the muscle (296.00 μg kg−1) on 5th day while in kidney (287.40 μg kg−1) it was on 13th day. On the ninth day, after the cessation of medicated feeding, the tissue residue (189.4 μg kg−1) was below the maximum residual limit (MRL) prescribed by the FAO Codex Alimentarius (200 μg kg−1) in the edible portion. These results help tropical countries like India to determine the safe dose and appropriate withdrawal time to ensure the safety of aquatic food products.
Indian Council of Agriculture Research
 
Date 2022-05-25T08:42:24Z
2022-05-25T08:42:24Z
2022-03-22
 
Type Research Paper
 
Identifier Solanki, H.G., Avunje, S., Raja, R.A., Trangadia, B.J., Verma, A., Vanza, J.G., Patel, M.R., Vala, R.B., Borichangar, R.V. and Patil, P.K., 2022. Evaluation of safety and withdrawal period of orally administered Oxytetracycline (OTC) in advance fingerlings of Cirrhinus mrigala (Hamilton, 1822). Aquaculture, 554, p.738167.
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http://krishi.icar.gov.in/jspui/handle/123456789/72389
 
Language English
 
Relation Not Available;
 
Publisher Elsevier