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The efects of extended feeding of forfenicol coated medicated diets on the safety, serum biomarkers and blood cells morphology of Nile tilapia Oreochromis niloticus (L.)

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Title The efects of extended feeding of forfenicol coated medicated diets on the safety, serum biomarkers and blood cells morphology of Nile tilapia Oreochromis niloticus (L.)
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Creator Avishek Bardhan, Thangapalam Jawahar Abraham, Jasmine Singha, Suchismita Saha, Sudeshna Sarker, Prasanna Kumar Patil
 
Subject Aquaculture, Antibiotics, Medicated feed, Biomass, Clinical biochemistry, Cytotoxicity
 
Description Not Available
Tilapia is one of the most consumed farmed fsh, which requires the use of antibiotics in certain phases of its production. This study assessed the safety of 30 days of oral forfenicol (FFC) dosing at 0–10 times the therapeutic dose (1×: 10 mg/kg biomass/day) in Oreochromis niloticus juveniles. Behavioural changes, feed consumption, mortality and biomass were evaluated. Besides, the levels of serum glucose, calcium, chloride, creatinine, alanine aminotransferase, aspartate aminotrans ferase, alkaline phosphatase and blood cell morphology were determined at scheduled intervals. The 30 days of oral FFC dosing caused 3.33% (1×) to 18.33% (10×) mortalities, reduced feed intake and biomass in a dose-dependent manner. The fsh fed the therapeutic dose recorded 1.25-fold increase in biomass, while the control group recorded 1.45-fold increase in 30 days. No signifcant erythrocyte morphological alterations were observed in the 1×group compared to the control. However, marked morphological alterations like tear-shaped, spindle-shaped and degenerative erythrocytes in higher dosing groups indicated FFC cytotoxicity. All the serum biomarkers of O. niloticus increased signifcantly on day 10 and day 30 FFC dosing in a dose-dependent manner, except for calcium and chloride, which reduced signifcantly during the dos ing period. Within 2 weeks of suspension of FFC dosing, the serum biomarker levels became normal except for alkaline phosphatase and creatinine. The recovery of biomass, feed intake, serum biomarker levels and erythrocyte morphological changes suggested that the FFC-induced changes are reversible. This study has, thus, proclaimed the safety of FFC at the therapeutic dose in O. niloticus.
Indian Council of Agriculture Research
 
Date 2022-05-25T08:41:35Z
2022-05-25T08:41:35Z
2022-02-03
 
Type Research Paper
 
Identifier Bardhan, A., Abraham, T.J., Singha, J., Saha, S., Sarker, S. and Patil, P.K., 2022. The effects of extended feeding of florfenicol coated medicated diets on the safety, serum biomarkers and blood cells morphology of Nile tilapia Oreochromis niloticus (L.). Environmental Science and Pollution Research, pp.1-14.
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http://krishi.icar.gov.in/jspui/handle/123456789/72388
 
Language English
 
Relation Not Available;
 
Publisher Springer Nature 2022