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Antioxidant defense of fish collagen peptides attenuates oxidative stress in gastric mucosa of experimentally ulcer-induced rats

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Title Antioxidant defense of fish collagen peptides attenuates oxidative stress in gastric mucosa of experimentally ulcer-induced rats
Not Available
 
Creator Divya K. Vijayan
Sreerekha, P. R.
Dara, P. K.
Ganesan, B.
Suseela Mathew
Anandan, R.
Ravishankar, C.N.
 
Subject Great hammerhead shark
Bioactivity
Gastroprotective
Inflammatory markers
Gross pathology
Histopathology
 
Description Not Available
The aim of the present study was to investigate the ability of fish collagen peptides (FCP) from the skin of great hammerhead shark (Sphyrna mokarran) to avert the occurrence of gastric ulcer in experimental rats. FCP treatment prevented the formation of ulcerative lesions on gastric tissues with 86% of inhibition. The histopathology analysis of gastric tissue revealed that the FCP intake prevented the occurrence of hemorrhage and erosion in gastric tissue with formation of mild edema and necrosis, as well as normalized the pH and volume of gastric juice. It also downregulated the expression of pro-inflammatory marker interferon-ɤ (IFN-ɤ) and upregulated the anti-inflammatory marker interleukin-4 (IL-4) in gastric tissue. FCP is capable to modulate the oxidative stress by enhancing the activity of antioxidant defense enzymes superoxide dismutase (SOD) and catalase and by lowering the levels of membrane lipid peroxidation.
Not Available
 
Date 2022-06-25T04:54:00Z
2022-06-25T04:54:00Z
2022
 
Type Research Paper
 
Identifier Divya K. Vijayan, Sreerekha, P. R., Dara, P. K., Ganesan, B., Suseela Mathew, Anandan, R. and Ravishankar, C. N. (2022) Antioxidant defense of fish collagen peptides attenuates oxidative stress in gastric mucosa of experimentally ulcer-induced rats. Cell Stress Chaperones. 27: 45-54.
1355-8145
http://krishi.icar.gov.in/jspui/handle/123456789/73424
 
Language English
 
Relation Not Available;
 
Publisher Springer