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Protective Effect of Squalene against Isoproterenol-Induced Myocardial Infarction in Rats

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Title Protective Effect of Squalene against Isoproterenol-Induced Myocardial Infarction in Rats
Not Available
 
Creator Sabeena, K.H.
Anandan, R.
Sankar, T. V.
Viswanathan Nair, P. G.
 
Subject squalene
isoproterenol
myocardial infarction
lipid peroxidation
mineral status
membrane-bound ATPases
 
Description Not Available
The protective effect of squalene on membrane function and mineral status was examined in isoproterenol-induced myocardial infarction in male albino rats. The pretreatment with squalene at 2% level along with feed significantly reduced the isoproterenol-induced rise in the levels of plasma diagnostic marker enzymes. It counteracted isoproterenol-induced lipid peroxidation in plasma and heart tissue, and maintained the level of reduced glutathione in the heart tissue at near normalcy. Supplementation of squalene also exerted membrane stabilizing action against isoproterenol-induced myocardial infarction by maintaining the activities of membrane-bound ATPases in heart tissue and the mineral status (sodium, potassium and calcium) in plasma and heart tissue at near normal levels. The cardioprotective effect of squalene might be ascribable to its antioxidant nature and membrane stabilizing property.
Not Available
 
Date 2021-11-29T08:08:26Z
2021-11-29T08:08:26Z
2005
 
Type Research Paper
 
Identifier Sabeena, K.H., Anandan, R., Sankar, T. V. and Viswanathan Nair, P. G. (2005) Protective effect of squaline against Isoproterenol induced myocardial infraction in rats, J. Cli. Biochem.Nutr., 37(2): 55-60.
1880-5086 (Online) 0912-0009 (Print)
http://krishi.icar.gov.in/jspui/handle/123456789/67963
 
Language English
 
Relation Not Available;
 
Publisher J-stage