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Cardio-protective effect of Thiamine and Pyridoxine loaded Vanillic acid grafted Chitosan micro-particles against Isoproterenol-induced myocardial Infarction in animal model

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Title Cardio-protective effect of Thiamine and Pyridoxine loaded Vanillic acid grafted Chitosan micro-particles against Isoproterenol-induced myocardial Infarction in animal model
Not Available
 
Creator Tejpal, C.S.
Elavarasan, K.
Lekshmi, R.G.K.
Chatterjee, N.S.
Sanal, E.
Mandakini Devi, H.
Anas, K.K.
Asha, K.K.
Anandan, R.
Suseela Mathew
 
Subject Vitamins
chitosan
vanillic acid
cardioprotection
myocardial infarction
 
Description Not Available
In the present study, the cardio-protective effect of
dietary supplementation of thiamine and pyridoxine
loaded vanillic acid grafted chitosan microparticles
(TPVGC) on isoproterenol induced myocardial
infarction in Wistar strain albino rats were studied.
Animals were distributed into four experimental
groups which were fed at graded level of levels
TPVGC for 45 days viz., Control (C) ; T1 ; T2 ; T3
for experimental period of 45 days. The possible role
of dietary TPVGC on cardioprotective effect was
assessed in terms of Serum LDH, IgG, Homocysteine, Serum Myglobin, troponin–T, CPK-MB, SGOT, S-GPT, and other metabolic enzyme assays. All
the assessed parameters were found to have significant difference between the control and treatment
groups. The biochemical markers such as troponin–
T, Serum LDH, CPK-MB, S-GOT, S-GPT, IgG,
Homocysteine, Serum Myglobin exhibited significant (p < 0.05) difference between the control and
treatment groups. Moreover, metabolic and antioxidant enzyme activity in the tissue levels also showed
significant (p < 0.05) difference between the control
and treatment groups. Results from the present
study, revealed that dietary supplementation of
thiamine and pyridoxine loaded vanillic acid grafted
chitosan microparticles at a minimum level of 1.6%
have protective effect on experimental myocardial
infarction induced by isoprenaline in rats.
Not Available
 
Date 2021-11-29T08:20:32Z
2021-11-29T08:20:32Z
2021-10
 
Type Research Paper
 
Identifier Tejpal, C.S., Elavarasan, K., Lekshmi, R.G.K., Chatterjee, N.S., Sanal, E., Mandakini Devi, H., Anas, K.K., Asha, K.K., Anandan, R. and Suseela Mathew (2021) Cardio-protective effect of Thiamine and Pyridoxine loaded Vanillic acid grafted Chitosan micro-particles against Isoproterenol-induced myocardial Infarction in animal model. Fish. Techol. 58 (4): 219-228.
0015-3001
http://krishi.icar.gov.in/jspui/handle/123456789/67967
 
Language English
 
Relation Not Available;
 
Publisher Society of Fisheries Technologists (India)