Record Details

Pharmacokinetics and physiometabolic response of single and multiple dose of fenbendazole in Labeo rohita (Hamilton, 1822) fingerlings.

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title Pharmacokinetics and physiometabolic response of single and multiple dose of fenbendazole in Labeo rohita (Hamilton, 1822) fingerlings.
Not Available
 
Creator Gupta G, Kumar M, Sardar, P., Varghese T, Srivastava, PP, Gupta S
 
Subject fenbendazole, HPLC, Labeo rohita, multiple dose, pharmacokinetics, single dose
 
Description Not Available
An experiment was carried to determine the plasma fenbendazole (FBZ) concentra-tion and physio-metabolic responses in juveniles of Labeo rohita (90± 4 g) after oral administration of single doses at 10, 20 and 50 mg, 20 mg FBZ/kg b.wt. in multiple times on 1st, 3rd and 7th day. The blood samples were collected at 0.5, 1, 2, 4, 8, 12, 24, 30, 48, 72, 96 and 120 hr, after single-dose administration, and regularly (upto 15 day) in multiple dose. Plasma FBZ concentration was determined up to the limit of detection (LoD) of 0.09 μg/ml by HPLC. There was no parent drug detected in plasma for administration of 10 mg FBZ/kg b.wt. The drug attained the peak concentration (Cmax) 1.85 and 3.09 μg/ml in plasma at 4 hr (Tmax) after administration of 20 and 50mg FBZ/kg b.wt. respectively. Plasma FBZ was detectable up to 96 and 120 hr with con-centration 0.09± 0.007 and 0.098± 0.006μg/ml, respectively, after single-dose administration of 20 and 50mg/kg b.wt. In case of multiple-dose administration, the maximum concentration of FBZ was 1.01 ± 0.03μg/ml on 7th day that was less than to the single dose at 50 mg/kg b.wt. However, FBZ was detected up to 11 day after multiple doses. The study revealed that the hepatic antioxidant enzymes activities like superoxide dismutase, catalase and glutathione-S-transferase were significantly affected by increasing FBZ in single and multiple doses. The results of the present study could reveal that single- or multiple-oral administration of FBZ at 20 mg/kg b.wt. in feed as antihelminthic drug in L. rohita could be considered as the safe dose.
Not Available
 
Date 2022-06-16T06:41:10Z
2022-06-16T06:41:10Z
2020-08-21
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/72646
 
Language English
 
Relation Not Available;
 
Publisher WILEY